2. Gene
  3. LHFPL4 - LHFPL tetraspan subfamily member 4 Gene

LHFPL4 - LHFPL tetraspan subfamily member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GARLH4

Gene ID: 375323 | Gene type: protein coding

About LHFPL4

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:9,498,361-9,553,822 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 6 paralogues. Biased expression in brain (RPKM 3.9) and adrenal (RPKM 0.5).

Summary

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. [provided by RefSeq, Jul 2008]

LHFPL4 Products(1)

mRNA Protein Name
NM_198560.3 NP_940962.1 LHFPL tetraspan subfamily member 4 protein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28978485 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHFPL4 Protein Structure

L_HMGIC_fpl

L_HMGIC_fpl: Lipoma HMGIC fusion partner-like protein (22 - 200)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

LHFPL tetraspan subfamily member 4 protein

GABAA receptor regulatory Lhfpl4

LHFPL4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LHFPL4 Q7Z7J7 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07628 LHFPL4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LHFPL4 RGD RGD:727967
Felis catus LHFPL4 VGNC VGNC:63222
Macaca mulatta LHFPL4 VGNC VGNC:110358
Mus musculus LHFPL4 MGD MGI:3057108
Bos taurus LHFPL4 VGNC VGNC:30867
Canis familiaris LHFPL4 VGNC VGNC:42659