1. Gene
  2. KIR2DL2 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 Gene

KIR2DL2 - killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 2 Gene

Homo sapiens

Also known as NKAT6; p58.2; CD158b; NKAT-6; CD158B1

Gene ID: 3803 | Gene type: protein coding

About KIR2DL2

Cytogenetic location: 19q13.4 Genomic coordinates (GRCh38): 19:50,900,001-58,617,616

Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

KIR2DL2 Products(1)

mRNA Protein Name
NM_014219.2 NP_055034.2 killer cell immunoglobulin-like receptor 2DL2 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18322206 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIR2DL2 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 117)

Ig_3

Ig_3: Immunoglobulin domain (123 - 198)

ig

ig: Immunoglobulin domain (237 - 294)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
Protein Preferred Names Protein Names

killer cell immunoglobulin-like receptor 2DL2

CD158 antigen-like family member B1

KIR2DL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KIR2DL2 P43627 HLA-C Homo sapiens P10321
Affinity Chrom
18322206
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant KIR2DL2 Proteins

Cat. No. Product Name Accession Purity
HY-P77970 KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) P43627 (H22-H245) ≥95%
HY-P77971 KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) P43627 (H22-H245) ≥95%