KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi)

KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) is 224 a.a., with molecular weight of 45-50 kDa.

KIR2DL2/CD158b1, located on natural killer (NK) cells, serves as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its primary function is to exert inhibitory effects on NK cell activity, acting as a regulator to prevent cellular lysis. Through specific interactions with distinct HLA-C molecules, KIR2DL2/CD158b1 contributes to the finely tuned balance of inhibitory signals within the immune system, influencing the responsiveness of NK cells to potential targets.

Human

HEK293

C-Avi;C-His

P43627 (H22-H245)

3803  [NCBI]

45-50 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.