KLK2 - kallikrein related peptidase 2 Gene

Homo sapiens

Also known as hK2; hGK-1; KLK2A2

Gene ID: 3817 | Gene type: protein coding

About KLK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,873,439-50,880,567 (from NCBI)

This gene has 23 transcripts (splice variants), 144 orthologues, 12 paralogues and is associated with 48 phenotypes. Restricted expression toward prostate (RPKM 1047.4).

Summary

This gene encodes a member of the grandular Kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine Protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate Cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

KLK2 Products(3)

mRNA	Protein	Name
NM_001002231.3	NP_001002231.1	kallikrein-2 isoform 2 preproprotein
NM_001256080.2	NP_001243009.1	kallikrein-2 isoform 3
NM_005551.5	NP_005542.1	kallikrein-2 isoform 1 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	9042371	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK2 Protein Structure

Trypsin

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

kallikrein-2

glandular kallikrein 2

Recombinant KLK2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70317	Kallikrein-2 Protein, Human (HEK293, His)	P20151-1 (P19-P261)	≥95%

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Prostate Disease

Prostatic Diseases

Prostate Diseases

Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia	BPH
Prostatic Hyperplasia

Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07380	KLK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Others	KLK2	NCBI

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