IL31 - interleukin 31 Gene

Homo sapiens

Also known as IL-31

Gene ID: 386653 | Gene type: protein coding

About IL31

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,172,029-122,174,221 (from NCBI)

This gene has 1 transcript (splice variant) and 69 orthologues. Low expression observed in reference dataset.

Summary

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating Other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

IL31 Products(1)

mRNA	Protein	Name
NM_001014336.2	NP_001014358.1	interleukin-31 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	21182835	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL31 Protein Structure

IL31

0
100
164 a.a.

Protein Preferred Names

Protein Names

interleukin-31

IL31 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL31	Q6EBC2	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL31 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7217	IL-31 Protein, Human	Q6EBC2 (S24-T164)	≥95%
HY-P73209	IL-31 Protein, Human (HEK293, His)	Q6EBC2/NP_001014358.1 (S24-T164)	≥95%
HY-P700123AF	Animal-Free IL-31 Protein, Human (His)	Q6EBC2 (S24-T164)	≥95%

Related Diseases

Diseases

Alias

Dermatitis

Eczema	Skin Inflammation
Inflammatory Dermatosis

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Contact Dermatitis

Contact Dermatitis/Eczema	Contact Eczema
Dermatitis Venenata	Dermatitis, Venenata
Dermatitis Contact	Dermatitis, Contact

Primary Cutaneous Amyloidosis

Plca	Primary Localized Cutaneous Amyloidosis
Familial Primary Localized Cutaneous Amyloidosis	Amyloidosis Ix
Lichen Amyloidosis Familial	Amyloidosis, Primary Cutaneous
Pca	Amyloidosis 9
Amyloidosis Familial Cutaneous Lichen	Fplca
Familial Lichen Amyloidosis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Dermatitis Herpetiformis

Duhring'S Disease	Duhring-Brocq Disease
Dermatosis Herpetiformis	Brocq-Duhring Disease
Dh	Duhring Brocq Disease
Dh - [Dermatitis Herpetiformis]

Mastocytosis, Cutaneous

Urticaria Pigmentosa	Cutaneous Mastocytosis
Diffuse Cutaneous Mastocytosis	Maculopapular Cutaneous Mastocytosis
Mastocytosis, Diffuse Cutaneous	MASTC
Mastocytosis, Maculopapular Cutaneous	Mastocytosis, Systemic, Somatic
Mastocytoma	Dcm
Diffuse Cutaneous Maculopapulous Mastocytosis	Up/Mpcm
Cm	Mastocytosis, Systemic
MASTSYS	Mast Cell Disease
Mast-Cell Disease	Mast Cell Leukemia
Mastocytosis, Indolent	Mastocytosis With Associated Hematologic Disorder
Mast Cell Neoplasm	Benign Mastocytoma

Neurodermatitis

Mite Infestation

Mite Infestations	Acariasis
Infestation By Mites Nos

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Pemphigoid

Eczema Herpeticum

Herpes Simplex Dermatitis	Herpes Simplex Eyelid Dermatitis
Kaposi Varicelliform Eruption	Herpes Simplex Dermatitis Of Eyelid
Herpes Simplex Virus Dermatitis	Herpes Simplex Virus Eyelid Dermatitis

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Scabies

Sarcoptic Itch	Infestation By Sarcoptes Scabiei
Infestation By Sarcoptes Scabiei Var Hominis	Infestation By Sarcoptes Scabiei Var. Hominis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Psoriasis

Irritant Dermatitis

Irritant Contact Dermatitis	Primary Irritant Dermatitis
Dermatitis, Irritant	Contact Dermatitis, Irritant
Irritant Contact Eczema	Icd - [Irritant Contact Dermatitis]
Irritant Contact Dermatitis, Unspecified Cause	Non-Allergic Contact Dermatitis
Irritant Contact Eczema Due To Wet Work	Irritant Contact Dermatitis Due To Detergents
Irritant Contact Eczema Due To Solvents	Irritant Contact Eczema Due To Exposure To Acids, Alkalis Or Other Chemical Irritants
Irritant Contact Eczema Due To Cosmetics Or Emollients	Irritant Contact Eczema Due To Topical Medicaments Or Antimicrobials
Irritant Contact Eczema Due To Plants Or Other Vegetable Matter	Irritant Contact Eczema Due To Foods
Irritant Contact Eczema Due To Friction, Sweating Or Contact With Body Fluids	Irritant Contact Eczema Due To Saliva
Irritant Contact Eczema Due To Incontinence	Incontinence-Associated Dermatitis

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Chronic Inducible Urticaria

Occupational Dermatitis

Dermatitis, Occupational	Occupational Allergic Contact Dermatitis
Occupational Eczema

Chronic Urticaria

Urticaria Chronic	Chronic Spontaneous Urticaria
Chronic Ordinary Urticaria

Fox-Fordyce Disease

Fox Fordyce Disease	Apocrine Miliaria
Fox-Fordyce Syndrome	Miliaria, Apocrine

Skin Atrophy

Atrophic Condition Of Skin	Atrophoderma
Atrophy - Skin

Luminal Breast Carcinoma B

Luminal B Breast Carcinoma

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Nasal Cavity Disease

Disorder Of Nasal Cavity

Nose Disease

Nose Diseases	Disorder Of The Nose
Nasal Disorder	Abnormality Of The Nose

Integumentary System Disease

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99162	Nemolizumab	Inhibitor	/	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99519	Vixarelimab	Inhibitor	≥95.0%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06754	IL31 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06755	IL31RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99301	Lokivetmab	Inhibitor	96.12%	Unkown
HY-P990713	Nolavetbart		/	Unkown
HY-P99864	Dovanvetmab		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL31	VGNC	VGNC:80444
Canis familiaris	IL31	VGNC	VGNC:41980
Macaca mulatta	IL31	VGNC	VGNC:108352
Mus musculus	IL31	MGD	MGI:1923649
Rattus norvegicus	IL31	RGD	RGD:1585183
Macaca fascicularis	IL31	NCBI	NCBI:102135935
Others	IL31	NCBI