2. Immunology/Inflammation
  3. Interleukin Related
  4. Nemolizumab

Nemolizumab (CIM331) is a humanized monoclonal antibody that targets the human interleukin-31 receptor a, preventing interleukin-31 (IL-31) from binding to its receptor and the subsequent signaling. Nemolizumab can help reduce itching and sleep disturbances, and it is being studied for atopic dermatitis (AD).

For research use only. We do not sell to patients.

CAS No. : 1476039-58-3

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Based on 1 publication(s) in Google Scholar

Nemolizumab Related Antibodies

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Description

Nemolizumab (CIM331) is a humanized monoclonal antibody that targets the human interleukin-31 receptor a, preventing interleukin-31 (IL-31) from binding to its receptor and the subsequent signaling. Nemolizumab can help reduce itching and sleep disturbances, and it is being studied for atopic dermatitis (AD)[1][2].

Isotype

Human IgG2 kappa
Recommend Isotype Controls
Species

Humanized
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Nemolizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized IL-31R alpha Protein, Human can bind Nemolizumab. The EC50 for this effect is 17.37 ng/mL.
Purity & Documentation
References
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Nemolizumab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemolizumab1476039-58-3CIM331CIM 331CIM-331Interleukin RelatedILIL-31/IL-31R signalingmonoclonal antibodyatopic dermatitisInhibitorinhibitorinhibit

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