Zhx2 - zinc fingers and homeoboxes 2 Gene

Mus musculus

Also known as Raf; Afr1; Afr-1; mKIAA0854

Gene ID: 387609 | Gene type: protein coding

About Zhx2

Chromosome 15: 57,558,061-57,703,228 forward strand.GRCm39:CM001008.3

This gene has 2 transcripts (splice variants), 237 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in genital fat pad adult (RPKM 5.9), spleen adult (RPKM 5.8) and 28 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in retinal bipolar neuron differentiation. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Is active in nucleus. Is expressed in brain; liver; and renal vasculature. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Apr 2022]

Zhx2 Products(1)

mRNA	Protein	Name
NM_199449.2	NP_955520.1	zinc fingers and homeoboxes protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8939998	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within mRNA catabolic process	IDA IDA: Inferred from direct assay	1370712	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	19515908	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19515908	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10673330	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	19515908	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	7523852	MGI
involved in retinal bipolar neuron differentiation	IMP IMP: Inferred from mutant phenotype	30146259	MGI
acts upstream of or within somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	19515908	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in nucleus	IDA IDA: Inferred from direct assay	17056598	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19515908	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Zhx2 Protein Structure

zf_C2H2_ZHX

homeodomain

HOX

homeodomain

0
200
400
600
836 a.a.

Protein Preferred Names

Protein Names

zinc fingers and homeoboxes protein 2

AFP regulator 1	alpha fetoprotein regulation 1, adult
alpha-fetoprotein regulator 1	regulator of AFP
zinc finger and homeodomain protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16069	ZHX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16070	Zhx2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16071	Zhx2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Zhx2	NCBI	NCBI:22882

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