2. Gene
  3. ZHX2 - zinc fingers and homeoboxes 2 Gene

ZHX2 - zinc fingers and homeoboxes 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RAF; AFR1

Gene ID: 22882 | Gene type: protein coding

About ZHX2

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:122,781,655-122,974,510 (from NCBI)

This gene has 2 transcripts (splice variants), 237 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 11.9) and 25 other tissues.

Summary

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

ZHX2 Products(11)

mRNA Protein Name
XM_047421585.1 XP_047277541.1 zinc fingers and homeoboxes protein 2 isoform X1
XM_047421584.1 XP_047277540.1 zinc fingers and homeoboxes protein 2 isoform X1
XM_047421589.1 XP_047277545.1 zinc fingers and homeoboxes protein 2 isoform X1
XM_005250836.6 XP_005250893.1 zinc fingers and homeoboxes protein 2 isoform X1
XM_047421588.1 XP_047277544.1 zinc fingers and homeoboxes protein 2 isoform X1
NM_001362797.2 NP_001349726.1 zinc fingers and homeoboxes protein 2
XM_047421590.1 XP_047277546.1 zinc fingers and homeoboxes protein 2 isoform X1
NM_014943.5 NP_055758.1 zinc fingers and homeoboxes protein 2
XM_047421586.1 XP_047277542.1 zinc fingers and homeoboxes protein 2 isoform X1
XM_011516932.4 XP_011515234.1 zinc fingers and homeoboxes protein 2 isoform X1
XM_047421587.1 XP_047277543.1 zinc fingers and homeoboxes protein 2 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12741956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12741956 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
12741956 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12741956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12741956 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12741956 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in nucleus IDA
IDA: Inferred from direct assay
17056598 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12741956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZHX2 Protein Structure

zf-H2C2_5

zf-H2C2_5: C2H2-type zinc-finger domain (110 - 134)

Homeobox

Homeobox: Homeobox domain (446 - 495)

Homeobox

Homeobox: Homeobox domain (537 - 581)

Homeobox

Homeobox: Homeobox domain (636 - 681)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
Protein Preferred Names Protein Names

zinc fingers and homeoboxes protein 2

AFP regulator 1

alpha-fetoprotein regulator 1

regulator of AFP

transcription factor ZHX2

zinc finger and homeodomain protein 2

ZHX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZHX2 Q9Y6X8 TFF2 Homo sapiens Q03403
Y2H Pooling
32814053
Intra
ZHX2 Q9Y6X8 TFF2 Homo sapiens Q03403
Validated Y2H
32814053
Intra
ZHX2 Q9Y6X8 TFF2 Homo sapiens Q03403
Y2H Array
32814053
Intra
ZHX2 Q9Y6X8 AIFM1 Homo sapiens O95831
Crosslink
30021884
Intra
ZHX2 Q9Y6X8 ZHX2 Homo sapiens Q9Y6X8
Y2H
12741956
Intra
ZHX2 Q9Y6X8 ZHX2 Homo sapiens Q9Y6X8
Pull Down
12741956
Intra
ZHX2 Q9Y6X8 Arfgap1 Rattus norvegicus Q62848
GTPase Assay
22363216
Cross: Cross-species interaction Intra: Intraspecies interaction

ZHX2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82001 ZHX2 Antibody (YA1746) WB, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin

Delta-Beta-Thalassemia

Delta-Beta Thalassemia

Delta Beta-Thalassemia

HBFQTL1

Hemoglobin F, Hereditary Persistence Of

Hpfh

Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related

Hemoglobin, Fetal, Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin Thalassemia

Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]

Fetal Haemoglobin

Persistence Of Fetal Haemoglobin

Persistent Haemoglobin F
Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency

Cox Deficiency

Cytochrome-C Oxidase Deficiency Disease

MC1DN4

Cytochrome-C Oxidase Deficiency

MC4DN1

Mitochondrial Complex I Deficiency, Nuclear Type 4

Complex 4 Mitochondrial Respiratory Chain Deficiency

Complex Iv Deficiency

Mitochondrial Complex 1 Deficiency, Nuclear Type 4

Nuclear Type Mitochondrial Complex I Deficiency 4

Deficiency Of Mitochondrial Respiratory Chain Complex4

MT-C4D

Complex Iv Mitochondrial Respiratory Chain Deficiency

Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
Nephrotic Syndrome, Type 23

NPHS23

Nephrotic Syndrome Type 23

Nephrotic Syndrome 23
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16069 ZHX2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16070 Zhx2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16071 Zhx2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZHX2 MGD MGI:2683087
Canis familiaris ZHX2 VGNC VGNC:48632
Bos taurus ZHX2 VGNC VGNC:37183
Rattus norvegicus ZHX2 RGD RGD:727926
Macaca mulatta ZHX2 VGNC VGNC:79148
Felis catus ZHX2 VGNC VGNC:67244