GFRAL - GDNF family receptor alpha like Gene

Homo sapiens

Also known as GRAL; UNQ9356; C6orf144; bA360D14.1

Gene ID: 389400 | Gene type: protein coding

About GFRAL

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,327,469-55,402,493 (from NCBI)

This gene has 1 transcript (splice variant), 174 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in glial cell-derived neurotrophic factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of protein kinase B signaling. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GFRAL Products(1)

mRNA	Protein	Name
NM_207410.2	NP_997293.2	GDNF family receptor alpha-like precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glial cell-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	28846097	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28846097	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	28846097	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in GDF15-GFRAL signaling pathway	IDA IDA: Inferred from direct assay	28953886	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	28846099	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	28846097	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28953886	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GFRAL Protein Structure

GDNF

0
100
200
300
394 a.a.

Protein Preferred Names

Protein Names

GDNF family receptor alpha-like

IVFI9356

Recombinant GFRAL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71580	GFRAL Protein, Human (His-SUMO)	Q6UXV0 (S19-E351)	≥95%
HY-P78135	GFRAL Protein, Human (Biotinylated, HEK293, His-Avi)	Q6UXV0 (S19-E351)	≥95%
HY-P78449	GFRAL Protein, Human (HEK293, His-Avi)	Q6UXV0 (S19-E351)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99241	Ponsegromab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05390	GFRAL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GFRAL	VGNC	VGNC:62532
Rattus norvegicus	GFRAL	RGD	RGD:1565220
Macaca mulatta	GFRAL	VGNC	VGNC:104386
Canis familiaris	GFRAL	VGNC	VGNC:41192
Bos taurus	GFRAL	VGNC	VGNC:53972
Mus musculus	GFRAL	MGD	MGI:3607786
Macaca fascicularis	GFRAL	NCBI	NCBI:102126381
Others	GFRAL	NCBI

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