2. Stem Cell/Wnt TGF-beta/Smad
  3. TGF-beta/Smad
  4. Ponsegromab

Ponsegromab  (Synonyms: PF 06946860)

Cat. No.: HY-P99241 Purity: 95.00%
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Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers.

For research use only. We do not sell to patients.

CAS No. : 2368950-15-4

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1 mg USD 380 In-stock
5 mg USD 840 In-stock
10 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

Ponsegromab Related Antibodies

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1 Publications Citing Use of MCE Ponsegromab

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Description

Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
IC50 & Target

GDF15[1]
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ponsegromab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation
References
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Ponsegromab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponsegromab2368950-15-4PF 06946860PF06946860PF-06946860TGF-beta/SmadTransforming growth factor betaAntibodyGDF15GFRALcancerInhibitorinhibitorinhibit

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