2. Gene
  3. KTN1 - kinectin 1 Gene

KTN1 - kinectin 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CG1; KNT; MU-RMS-40.19

Gene ID: 3895 | Gene type: protein coding

About KTN1

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,580,207-55,684,584 (from NCBI)

This gene has 25 transcripts (splice variants), 206 orthologues and is associated with 76 phenotypes. Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues.

Summary

This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds Kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

KTN1 Products(32)

mRNA Protein Name
NM_001079521.2 NP_001072989.1 kinectin isoform a
NM_001079522.2 NP_001072990.1 kinectin isoform b
NM_001271014.2 NP_001257943.1 kinectin isoform d
NM_001402682.1 NP_001389611.1 kinectin isoform a
NM_001402683.1 NP_001389612.1 kinectin isoform 5
NM_001402684.1 NP_001389613.1 kinectin isoform 6
NM_001402685.1 NP_001389614.1 kinectin isoform d
NM_001402686.1 NP_001389615.1 kinectin isoform d
NM_001402687.1 NP_001389616.1 kinectin isoform 7
NM_001402688.1 NP_001389617.1 kinectin isoform 7
NM_001402689.1 NP_001389618.1 kinectin isoform 7
NM_001402690.1 NP_001389619.1 kinectin isoform b
NM_001402691.1 NP_001389620.1 kinectin isoform b
NM_001402692.1 NP_001389621.1 kinectin isoform 8
NM_001402693.1 NP_001389622.1 kinectin isoform c
NM_001402694.1 NP_001389623.1 kinectin isoform c
NM_001402696.1 NP_001389625.1 kinectin isoform 9
NM_001402698.1 NP_001389627.1 kinectin isoform 10
NM_001402699.1 NP_001389628.1 kinectin isoform 11
NM_001402700.1 NP_001389629.1 kinectin isoform 11
NM_001402701.1 NP_001389630.1 kinectin isoform 12
NM_001402702.1 NP_001389631.1 kinectin isoform 12
NM_001402703.1 NP_001389632.1 kinectin isoform 13
NM_001402704.1 NP_001389633.1 kinectin isoform 14
NM_001402705.1 NP_001389634.1 kinectin isoform 14
NM_001402706.1 NP_001389635.1 kinectin isoform 15
NM_001402707.1 NP_001389636.1 kinectin isoform 16
NM_001402708.1 NP_001389637.1 kinectin isoform 17
NM_001402709.1 NP_001389638.1 kinectin isoform 18
NM_001402710.1 NP_001389639.1 kinectin isoform 19
NM_001402711.1 NP_001389640.1 kinectin isoform 20
NM_004986.4 NP_004977.2 kinectin isoform c
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinectin

CG-1 antigen

KTN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KTN1 Q86UP2 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra KTN1 Q86UP2 CLEC7A Homo sapiens Q9BXN2
Y2H Prey Pooling
25416956
Intra KTN1 Q86UP2 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra KTN1 Q86UP2 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gliofibroma
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07477 KTN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KTN1 RGD RGD:1308719
Bos taurus KTN1 VGNC VGNC:30756
Felis catus KTN1 VGNC VGNC:67997
Macaca mulatta KTN1 VGNC VGNC:74222
Canis familiaris KTN1 VGNC VGNC:42550
Mus musculus KTN1 MGD MGI:109153