IZUMO1R - IZUMO1 receptor, JUNO Gene

Homo sapiens

Also known as JUNO; FOLR4; Folbp3; FR-delta

Gene ID: 390243 | Gene type: protein coding

About IZUMO1R

Cytogenetic location: 11q21 Genomic coordinates (GRCh38): 11:94,304,580-94,308,146 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

Enables signaling receptor activity. Predicted to be involved in cell adhesion; fusion of sperm to egg plasma membrane involved in single fertilization; and sperm-egg recognition. Predicted to be located in extracellular region and plasma membrane. Predicted to be anchored component of external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

IZUMO1R Products(2)

mRNA	Protein	Name
NM_001199206.4	NP_001186135.1	sperm-egg fusion protein Juno precursor
NM_001393610.1	NP_001380539.1	sperm-egg fusion protein Juno precursor

IZUMO1R Protein Structure

Folate_rec

0
100
200
243 a.a.

Protein Preferred Names

Protein Names

sperm-egg fusion protein Juno

IZUMO1 receptor protein JUNO

Recombinant IZUMO1R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77936	FOLR4 Protein, Human (HEK293, His)	A6ND01-1 (G20-S228)	≥95%

Related Diseases

Diseases

Alias

Subacute Leukemia

Biotin Deficiency

Biotin Deficiency Disease	B7 Deficiency
Biotan Vitamin Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07005	IZUMO1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IZUMO1R	RGD	RGD:1585174
Mus musculus	IZUMO1R	MGD	MGI:1929185
Bos taurus	IZUMO1R	VGNC	VGNC:106788
Felis catus	IZUMO1R	VGNC	VGNC:62992
Canis familiaris	IZUMO1R	VGNC	VGNC:59053
Macaca mulatta	IZUMO1R	VGNC	VGNC:101294
Others	IZUMO1R	NCBI

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