LBP - lipopolysaccharide binding protein Gene

Homo sapiens

Also known as BPIFD2

Gene ID: 3929 | Gene type: protein coding

About LBP

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,346,482-38,377,013 (from NCBI)

This gene has 1 transcript (splice variant), 104 orthologues and 12 paralogues. Restricted expression toward liver (RPKM 139.3).

Summary

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative Bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

LBP Products(1)

mRNA	Protein	Name
NM_004139.5	NP_004130.2	lipopolysaccharide-binding protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IPI IPI: Inferred from physical interaction	15294986	GOA
enables lipopeptide binding	IDA IDA: Inferred from direct assay	15294986	GOA
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	12594207	GOA
enables lipopolysaccharide binding	IMP IMP: Inferred from mutant phenotype	24120359	GOA
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	12594207	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	12932360	GOA
involved in cell surface pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	15294986	GOA
acts upstream of or within cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	12594207	GOA
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	24120359	GOA
acts upstream of or within cellular response to lipoteichoic acid	IDA IDA: Inferred from direct assay	12594207	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	11528597	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12932360	GOA
involved in detection of molecule of bacterial origin	IDA IDA: Inferred from direct assay	11528597	GOA
involved in lipopolysaccharide transport	IDA IDA: Inferred from direct assay	8985160	GOA
involved in lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	8409400	GOA
involved in macrophage activation involved in immune response	IMP IMP: Inferred from mutant phenotype	24120359	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	11739189	GOA
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of macrophage activation	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	11528597	GOA
acts upstream of or within positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	12594207	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	8409400	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	24120359	GOA
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	8409400	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	11528597	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	2402637	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lipopolysaccharide-binding protein

BPI fold containing family D, member 2

LBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LBP	P18428	BDNF	Homo sapiens	P23560-2	Y2H Pooling	32814053
Intra	LBP	P18428	BDNF	Homo sapiens	P23560-2	Validated Y2H	32814053
Intra	LBP	P18428	BDNF	Homo sapiens	P23560-2	Y2H Array	32814053
Intra	LBP	P18428	PRDX4	Homo sapiens	Q13162	Y2H	21988832
Intra	LBP	P18428	PRDX4	Homo sapiens	Q13162	Confocal	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LBP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70313	LBP Protein, Human (HEK293, His)	P18428 (A26-V481)	≥95%
HY-P78664	LBP Protein, Human (I465F, HEK293, His)	P18428 (A26-V481, I465F)	≥95%

Related Diseases

Diseases

Alias

Alcoholic Hepatitis

Acute Alcoholic Hepatitis	Acute Alcoholic Liver Disease
Hepatitis, Alcoholic	Hepatitis Alcoholic
Ah - [Alcoholic Hepatitis]	Ethanol Hepatitis

Toxic Pneumonitis

Acute Chemical Fume Pulmonary Edema	Acute Chemical Pulmonary Edema
Acute Pulmonary Edema Due To Fumes And/Or Vapors

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Reactive Arthritis

Postdysenteric Arthropathy	Reiter Disease
Pira	Reiter Syndrome
Reiters Syndrome	Arthritis, Reactive
Fiessinger Leroy Reiter Syndrome	Post-Bacterial Arthropathy
Reiter'S Disease	Post-Infectious Arthritis
Post-Infectious Reactive Arthropathy	Reiter'S Syndrome
Arthritis Urethritica	Fiessinger-Leroy Disease
Polyarthritis Enterica	Venereal Arthritis
Arthritis Reactive	Post-Dysenteric Arthropathy
Arthritis, Venereal

Mastitis

Breast Inflammation	Inflammatory Breast Disease
Inflammatory Disease Of Breast	Inflammation Of Non-Human Mammary Gland
Inflammatory Disorder Of Breast	Mastitis Nos
Acute Mastitis Nos	Acute Nonpuerperal Mastitis
Nonpuerperal Mastitis Nos	Subacute Mastitis Nos

Toxic Shock Syndrome

Septic Shock	Toxic Shock
Tss	Shock, Septic
Staphylococcal Toxic Shock Syndrome	Tss - [Toxic Shock Syndrome]

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome	Ards
Non-Cardiogenic Pulmonary Edema	Acute Lung Injury
Respiratory Distress Syndrome, Adult	Shock Lung
Acute Respiratory Distress	Respiratory Distress Syndrome
Adult Rds	Ali
Increased-Permeability Pulmonary Edema	Stiff Lung
Respiratory Distress Syndrome Adult

Appendicitis

Acute Appendicitis	Acute Appendicitis With Generalized Peritonitis
Acute Appendicitis Nos	Acute Appendicitis With Peritoneal Abscess
Appendiceal Inflammation	Appendicitis, Unqualified
Acute Appendix Inflammation	Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation
Acute Appendicitis With Free Peritonitis	Acute Appendicitis With Free Perforation To The Abdominal Cavity
Perforated Appendix With Generalised Peritonitis	Appendicitis With Perforation And Free Pus In The Peritoneal Cavity
Perforated Appendix With Localised Peritonitis	Acute Appendicitis With Contained Perforation To A Localised Abscess
Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation	Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation
Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess	Appendicitis With Abscess
Appendicitis With Peritoneal Abscess	Ruptured Appendix Nos
Acute Appendicitis With No Perforation Or Abscess And No Visible Pus	Acute Appendicitis With No Specification If Perforated Or Not
Acute Appendicitis With Phlegmone

Endocarditis

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Leptospirosis

Fort Bragg Fever	Weil Disease
Leptospirosis Icterohaemorrhagica	Nanukayami Fever
Canicola Fever	Hemorrhagic Jaundice
Mud Fever	Stuttgart Disease
Swamp Fever	Rat Catcher'S Yellows
Spirochetal Jaundice	Weil'S Disease
Cane-Cutter Fever	Icterohemorrhagic Fever
Rice-Field Fever	Swineherd'S Disease
Weil Syndrome	Nanukayami
Canine Leptospirosis	Equine Infectious Anemia
Leptospirosis Canicola	Fever Due To Leptospira Autumnalis
Gikiyami	Leptospira Interrogans Autumnalis Infection
Leptospira Interrogans Canicola Infection	Leptospira Interrogans Hebdomadis Infection
Leptospira Interrogans Pomona Infection	Nanukayami Disease
Pretibial Fever	Seven-Day Fever
Eia - [Equine Infectious Anaemia]	Leptospira Interrogans Infection

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Filariasis

Disease Due To Superfamily Filarioidea	Bancroftian Filarial Fever
Mumu	Wanganga
Bancroftian Filariasis	Wuchereriosis
Brugiosis	Malayan Filariasis

Meningitis

Streptococcal Meningitis	Acute Streptococcal Meningitis
Staphylococcal Meningitis	Adenoviral Meningitis
Influenza Meningitis	Influenzal Meningitis
Meningitis Due To H. Influenzae	Cryptococcal Meningitis
Fungal Meningitis Due To Cryptococcus Neoformans	Cryptococcosis Meningitis
Cryptococcus Meningitis	Cryptococcal Meningoencephalitis
Meningitis Due To Cryptococcus	Mumps Virus Meningitis
Mumps Meningitis

Bacteremia 2

Bacteremia	Bacteremia, Susceptibility To, 2
BACTS2	Bacteremia, Susceptibility To
Bacteremia, Susceptibility To, Type 2

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141882	DC-LC3in-D5	Inhibitor	98.51%	Unkown
HY-106010	LBP1	Agonist	/	Unkown
HY-155437	NEt-iFQ	Agonist	/	Unkown
HY-RS07543	LBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07544	Lbp Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LBP	RGD	RGD:61865
Mus musculus	LBP	MGD	MGI:1098776
Bos taurus	LBP	VGNC	VGNC:56192
Macaca mulatta	LBP	VGNC	VGNC:74240
Macaca fascicularis	LBP	NCBI	NCBI:102124806
Others	LBP	NCBI

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