2. Gene
  3. RHOH - ras homolog family member H Gene

RHOH - ras homolog family member H Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TTF; ARHH

Gene ID: 399 | Gene type: protein coding

About RHOH

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:40,191,080-40,246,967 (from NCBI)

This gene has 17 transcripts (splice variants), 184 orthologues, 22 paralogues and is associated with 53 phenotypes. Biased expression in lymph node (RPKM 20.2), bone marrow (RPKM 10.8) and 8 other tissues.

Summary

The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing Enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]

RHOH Products(12)

mRNA Protein Name
NM_001278359.2 NP_001265288.1 rho-related GTP-binding protein RhoH precursor
NM_001278360.2 NP_001265289.1 rho-related GTP-binding protein RhoH precursor
NM_001278361.2 NP_001265290.1 rho-related GTP-binding protein RhoH precursor
NM_001278362.2 NP_001265291.1 rho-related GTP-binding protein RhoH precursor
NM_001278363.2 NP_001265292.1 rho-related GTP-binding protein RhoH precursor
NM_001278364.2 NP_001265293.1 rho-related GTP-binding protein RhoH precursor
NM_001278365.2 NP_001265294.1 rho-related GTP-binding protein RhoH precursor
NM_001278366.2 NP_001265295.1 rho-related GTP-binding protein RhoH precursor
NM_001278367.2 NP_001265296.1 rho-related GTP-binding protein RhoH precursor
NM_001278368.2 NP_001265297.1 rho-related GTP-binding protein RhoH precursor
NM_001278369.2 NP_001265298.1 rho-related GTP-binding protein RhoH precursor
NM_004310.5 NP_004301.1 rho-related GTP-binding protein RhoH precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTP binding IDA
IDA: Inferred from direct assay
11809807 GOA
enables kinase inhibitor activity IDA
IDA: Inferred from direct assay
11809807 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11809807 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
11809807 GOA
involved in positive regulation of T cell differentiation IMP
IMP: Inferred from mutant phenotype
22850876 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11809807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOH Protein Structure

Ras

Ras: Ras family (6 - 170)

  • 0
  • 100
  • 191 a.a.
Protein Preferred Names Protein Names

rho-related GTP-binding protein RhoH

GTP-binding protein TTF

RHOH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RHOH Q15669 IQUB Homo sapiens Q8NA54
Validated Y2H
32296183
Intra RHOH Q15669 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra RHOH Q15669 SORL1 Homo sapiens Q92673
Validated Y2H
32296183
Intra RHOH Q15669 PLEKHA7 Homo sapiens Q6IQ23-2
Validated Y2H
32296183
Intra RHOH Q15669 XPNPEP1 Homo sapiens Q9NQW7-3
Validated Y2H
32296183
Intra RHOH Q15669 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra RHOH Q15669 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra RHOH Q15669 TCF19 Homo sapiens Q9Y242
Validated Y2H
32296183
Intra RHOH Q15669 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epidermodysplasia Verruciformis 4

Epidermodysplasia Verruciformis, Susceptibility To, 4

EV4

T-Cell Immunodeficiency With Epidermodysplasia Verruciformis

T-Cell Immunodeficiency Due To Rhoh Deficiency

{Epidermodysplasia Verruciformis, Susceptibility To, 4}
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur
Skin Carcinoma

Skin Cancer

Carcinoma Of Skin

Ca - Skin Cancer

Cancer Of Skin

Malignant Neoplasm Of Skin

Melanoma And Non-Melanoma Skin Cancer

Skin Cancers

Cancer, Skin
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev
Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11954 RHOH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RHOH VGNC VGNC:68162
Canis familiaris RHOH VGNC VGNC:45561
Macaca mulatta RHOH VGNC VGNC:76884
Mus musculus RHOH MGD MGI:1921984
Bos taurus RHOH VGNC VGNC:33950
Rattus norvegicus RHOH RGD RGD:1307623