TCF19 - transcription factor 19 Gene

Homo sapiens

Also known as SC1; TCF-19

Gene ID: 6941 | Gene type: protein coding

About TCF19

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,158,589-31,164,215 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 189 orthologues. Ubiquitous expression in lymph node (RPKM 8.0), appendix (RPKM 5.7) and 25 other tissues.

Summary

This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and Apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

TCF19 Products(3)

mRNA	Protein	Name
NM_001077511.2	NP_001070979.1	transcription factor 19
NM_001318908.2	NP_001305837.1	transcription factor 19
NM_007109.3	NP_009040.2	transcription factor 19

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF19 Protein Structure

FHA

PHD

0
100
200
300
345 a.a.

Protein Preferred Names

Protein Names

transcription factor 19

transcription factor SC1

TCF19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TCF19	Q9Y242	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	32296183
Intra	TCF19	Q9Y242	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	TCF19	Q9Y242	NOXA1	Homo sapiens	Q86UR1-2	Y2H Array	32296183
Intra	TCF19	Q9Y242	NOXA1	Homo sapiens	Q86UR1-2	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	RHOH	Homo sapiens	Q15669	Y2H Array	32296183
Intra	TCF19	Q9Y242	RHOH	Homo sapiens	Q15669	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	ZNF474	Homo sapiens	Q6S9Z5	Y2H Array	32296183
Intra	TCF19	Q9Y242	ZNF474	Homo sapiens	Q6S9Z5	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	TCF19	Q9Y242	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	32296183
Intra	TCF19	Q9Y242	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	TCF19	Q9Y242	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	TCF19	Q9Y242	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TCF19	Q9Y242	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	TCF19	Q9Y242	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	TCF19	Q9Y242	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	TCF19	Q9Y242	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	TCF19	Q9Y242	E2F6	Homo sapiens	O75461	Anti Tag CoIP	28514442
Intra	TCF19	Q9Y242	E2F6	Homo sapiens	O75461	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Psoriasis 8

PSORS8	Psoriasis Susceptibility 8
Psoriasis 8, Susceptibility To

Psoriasis 9

PSORS9	Psoriasis 9, Susceptibility To
Psoriasis Susceptibility 9

Psoriasis 7

PSORS7	Psoriasis 7, Susceptibility To
Psoriasis Susceptibility 7	Psoriasis
Psoriasis Vulgaris	Pv

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14301	TCF19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TCF19	RGD	RGD:1302974
Macaca mulatta	TCF19	VGNC	VGNC:83493
Felis catus	TCF19	VGNC	VGNC:66022
Canis familiaris	TCF19	VGNC	VGNC:47191
Bos taurus	TCF19	VGNC	VGNC:35688
Mus musculus	TCF19	MGD	MGI:103180

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