MEX3D - mex-3 RNA binding family member D Gene

Homo sapiens

Also known as MEX3; TINO; RKHD1; MEX-3D; RNF193; OK/SW-cl.4

Gene ID: 399664 | Gene type: protein coding

About MEX3D

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,554,672-1,568,325 (from NCBI)

This gene has 2 transcripts (splice variants), 167 orthologues and 3 paralogues. Broad expression in testis (RPKM 6.0), fat (RPKM 4.9) and 24 other tissues.

Summary

Enables mRNA 3'-UTR AU-rich region binding activity. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MEX3D Products(2)

mRNA	Protein	Name
NM_001174118.2	NP_001167589.1	RNA-binding protein MEX3D isoform 2
NM_203304.4	NP_976049.3	RNA-binding protein MEX3D isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	14769789	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14769789	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	14769789	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEX3D Protein Structure

KH_1

zf-C3HC4_3

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names

Protein Names

RNA-binding protein MEX3D

RING finger and KH domain-containing protein 1

Related Diseases

Diseases

Alias

Arthrogryposis, Distal, Type 5

Oculomelic Amyoplasia	Distal Arthrogryposis Type 5
Distal Arthrogryposis Type Iib	DA5
Arthrogryposis With Oculomotor Limitation And Electroretinal Abnormalities	Daiib
Distal Arthrogryposis Type 2b	Arthrogryposis-Oculomotor Limitation-Electroretinal Anomalies Syndrome
Distal Arthrogryposis With Ophthalmoplegia	Arthrogryposis- Oculomotor Limitation-Electroretinal Anomalies Syndrome
Arthrogryposis, Distal, Type Iib	Da2b
Freeman-Sheldon Syndrome Variant	Sheldon-Hall Syndrome
Arthogryposis With Oculomotor Limitation And Electroretinal Abnormalities	Arthrogryposis Ophthalmoplegia Retinopathy
Arthrogryposis, Distal, 5	Arthrogryposis, Distal, Type 2b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08375	MEX3D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEX3D	RGD	RGD:1310576
Mus musculus	MEX3D	MGD	MGI:2681847
Bos taurus	MEX3D	VGNC	VGNC:106821
Canis familiaris	MEX3D	VGNC	VGNC:81279

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