2. Gene
  3. SHC4 - SHC adaptor protein 4 Gene

SHC4 - SHC adaptor protein 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RaLP; SHCD

Gene ID: 399694 | Gene type: protein coding

About SHC4

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:48,823,741-48,963,919 (from NCBI)

This gene has 6 transcripts (splice variants), 179 orthologues and 3 paralogues. Biased expression in testis (RPKM 6.4), brain (RPKM 2.8) and 5 other tissues.

Summary

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC4 Products(1)

mRNA Protein Name
NM_203349.4 NP_976224.3 SHC-transforming protein 4
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24658140 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHC4 Protein Structure

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (192 - 347)

SH2

SH2: SH2 domain (527 - 597)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 630 a.a.
Protein Preferred Names Protein Names

SHC-transforming protein 4

SH2 domain protein C4

Related Diseases

Diseases Alias
Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder

Obsessive-Compulsive Personality

Compulsive Personality Disorder

Ocpd

Obsessional Personality Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161464 Chlopynostat / Unkown
HY-RS12859 SHC4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SHC4 MGD MGI:2655364
Rattus norvegicus SHC4 RGD RGD:1583644
Felis catus SHC4 VGNC VGNC:80847
Bos taurus SHC4 VGNC VGNC:106925
Macaca mulatta SHC4 VGNC VGNC:77249
Canis familiaris SHC4 VGNC VGNC:46142