2. Gene
  3. LYZ - lysozyme Gene

LYZ - lysozyme Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LZM; LYZF1

Gene ID: 4069 | Gene type: protein coding

About LYZ

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,348,381-69,354,234 (from NCBI)

This gene has 3 transcripts (splice variants), 407 orthologues, 8 paralogues and is associated with 2 phenotypes. Biased expression in stomach (RPKM 5710.8), salivary gland (RPKM 4398.2) and 8 other tissues.

Summary

This gene encodes human lysozyme, whose natural substrate is the Bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has Antibacterial activity against a number of Bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]

LYZ Products(1)

mRNA Protein Name
NM_000239.3 NP_000230.1 lysozyme C precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23353684 GOA
Biological Process GO Annotation Evidence Reference Source
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
21093056 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
21093056 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
9727055 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
21805676 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYZ Protein Structure

Lys

Lys: C-type lysozyme/alpha-lactalbumin family (19 - 146)

  • 0
  • 100
  • 148 a.a.
Protein Preferred Names Protein Names

lysozyme C

1,4-beta-N-acetylmuramidase C

LYZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LYZ P61626 IKBKB Homo sapiens O14920
TAP
14743216
Intra
LYZ P61626 NFKBIB Homo sapiens Q15653
TAP
14743216
Intra
LYZ P61626 CFP Homo sapiens P27918
ELISA
24355864
Intra
LYZ P61626 LYZ Homo sapiens P61626
Light Scattering
23353684
Intra
LYZ P61626 LYZ Homo sapiens P61626
EM
23353684
Intra
LYZ P61626 gpmI Bacillus anthracis Q81X77
Y2H Pooling
20711500
Intra
LYZ P61626 LYZ Homo sapiens P61626
Fluorescence
23353684
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYZ Proteins

Cat. No. Product Name Accession Purity
HY-P70390 Lysozyme C/LYZ Protein, Human (HEK293, His) P61626 (K19-V148) ≥95%

LYZ Antibodies

Cat. No. Product Name Application Reactivity
HY-P80748 Lysozyme Antibody WB, IHC-P Human

Related Diseases

Diseases Alias
Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis

German Type Amyloidosis

Familial Renal Amyloidosis

Amyloidosis Viii

Amyloidosis, 3 Or More Types

Familial Visceral Amyloidosis

Familial Amyloid Nephropathy

Hereditary Amyloid Nephropathy

Amyloidosis, Familial Renal

Amyloidosis, Systemic Nonneuropathic

Amyloidosis Familial Visceral

Amyloidosis 8

Amyloidosis, Ostertag Type

Hereditary Amyloidosis With Primary Renal Involvement

Hereditary Renal Amyloidosis

Renal Amyloidosis

Amyloidosis, Renal

Systemic Nonneuropathic Amyloidosis

Amyloidosis Familial Renal

Amyloidosis Systemic Nonneuropathic

Hereditary Amyloidosis With Primary Renal Involement

AMYL8

Systemic Non-Neuropathic Amyloidosis

Amyloid Nephropathy
Immunoglobulin Light Chain Amyloidosis

Al Amyloidosis

Primary Amyloidosis

Primary Systemic Amyloidosis

Light Chain Amyloidosis

Amyloidosis Al

Amyloidosis Primary Systemic

Primary Al Amyloidosis

Primary Systemic Al Amyloidosis

Systemic Al Amyloidsis

Systemic Al Amyloidosis

Light-Chain Amyloidosis

Alys Amyloidosis

Familial Amyloid Nephropathy Due To Lysozyme Variant

Familial Renal Amyloidosis Due To Lysozyme Variant

Hereditary Amyloid Nephropathy Due To Lysozyme Variant

Hereditary Renal Amyloidosis Due To Lysozyme Variant

Lysozyme Amyloidosis

Amyloidosis Primary

Immunoglobulin Deposition Disease

Immunoglobulinic Amyloidosis

Amyloid Al
Amyloidosis

Amyloid Disease

Amyloid

Amyloid Degeneration

Amyloidosis Nos

Amyloid Deposition

Amyloid Infiltration

Idiopathic Amyloidosis

Hyaloid Degeneration

Lardaceous Degeneration
Tuberculous Meningitis

Tubercular Meningitis

Tb Meningitis

Tuberculosis, Meningeal

Tbm

Meningitis Tuberculous

Tbm - [Tuberculous Meningitis]

Meningitis Due To Mycobacterium Tb

Caseous Meningitis

Tuberculous Meninges Adhesions

Tuberculous Leptomeningitis

Meningeal Tuberculosis

Meningeal Tb

Meningeal Tbc - [Tuberculosis]
Malignant Adenofibroma

Adenocarcinofibroma
Meningitis

Streptococcal Meningitis

Acute Streptococcal Meningitis

Staphylococcal Meningitis

Adenoviral Meningitis

Influenza Meningitis

Influenzal Meningitis

Meningitis Due To H. Influenzae

Cryptococcal Meningitis

Fungal Meningitis Due To Cryptococcus Neoformans

Cryptococcosis Meningitis

Cryptococcus Meningitis

Cryptococcal Meningoencephalitis

Meningitis Due To Cryptococcus

Mumps Virus Meningitis

Mumps Meningitis
Isthmus Cancer
Hereditary Amyloidosis

Amyloidosis Hereditary

Familial Amyloidosis

Amyloidosis Familial

Amyloidosis, Hereditary

Amyloidosis, Familial

Genetic Amyloidosis

Heredofamilial Amyloidosis
Opportunistic Bacterial Infectious Disease
Nocardiosis

Nocardia Infection

Nocardia Infections

Nocardia Infectious Disease

Lung Nocardiosis

Nocardiasis

Nocardiosis Nos
Bacterial Meningitis

Meningitis, Bacterial

Meningitis Bacterial

Bm - [Bacterial Meningitis]

Leptomeningitis Bacterial

Pachymeningitis Bacterial

Arachnoiditis Bacterial
Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay
Anaerobic Pneumonia

Pneumonia Due To Anaerobes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07930 LYZ Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W109513 Boc-Lys(Z)-OH (DCHA) / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LYZ VGNC VGNC:74466
Canis familiaris LYZ VGNC VGNC:42901
Rattus norvegicus LYZ RGD RGD:3026
Felis catus LYZ VGNC VGNC:68114
Others LYZ NCBI