TACSTD2 - tumor associated calcium signal transducer 2 Gene

Homo sapiens

Also known as EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1

Gene ID: 4070 | Gene type: protein coding

About TACSTD2

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:58,575,433-58,577,252 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues, 1 paralogue and is associated with 3 phenotypes.

Summary

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

TACSTD2 Products(1)

mRNA	Protein	Name
NM_002353.3	NP_002344.2	tumor-associated calcium signal transducer 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15607035	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACSTD2 Protein Structure

Thyroglobulin_1

0
100
200
300
323 a.a.

Protein Preferred Names

Protein Names

tumor-associated calcium signal transducer 2

40kD glycoprotein, identified by monoclonal antibody GA733

TACSTD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TACSTD2	P09758	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	TACSTD2	P09758	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	TACSTD2	P09758	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	TACSTD2	P09758	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	TACSTD2	P09758	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	TACSTD2	P09758	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	TACSTD2	P09758	KRTAP5-2	Homo sapiens	Q701N4	Validated Y2H	32296183
Intra	TACSTD2	P09758	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	TACSTD2	P09758	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	TACSTD2	P09758	LCE2C	Homo sapiens	Q5TA81	Validated Y2H	32296183
Intra	TACSTD2	P09758	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TACSTD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70457	TROP-2 Protein, Human (248a.a, HEK293, His)	P09758 (H27-T274)	≥95%
HY-P70770	TROP-2 Protein, Human (HEK293, His-Avi)	P09758 (H27-T274)	≥95%
HY-P70728	TROP-2 Protein, Human (187a.a, HEK293, His)	P09758 (T88-T274)	≥95%
HY-P71095	TROP-2 Protein, Human (187a.a, HEK293, Fc)	P09758 (T88-T274)	≥95%
HY-P72015	TROP-2 Protein, Human (248a.a, HEK293, hFc)	P09758 (H27-T274)	≥95%
HY-P74490	TROP-2 Protein, Human (HEK293, His-hFc)	P09758 (H27-T274)	≥95%
HY-P78223	TROP-2 Protein, Human (Biotinylated, HEK293, His-Avi)	P09758 (H27-T274)	≥95%
HY-P78539	TROP-2 Protein, Human (FITC, HEK293, His)	P09758 (H27-T274)	≥95%

Related Diseases

Diseases

Alias

Corneal Dystrophy, Gelatinous Drop-Like

Gelatinous Drop-Like Corneal Dystrophy	GDLD
Cdgdl	Corneal Amyloidosis
Lattice Corneal Dystrophy Type Iii	Amyloidosis, Corneal
Amyloid Corneal Dystrophy, Japanese Type	Gdcd
Primary Familial Amyloidosis Of The Cornea	Subepithelial Amyloidosis Of The Cornea
Corneal Dystrophy, Lattice Type 3	Corneal Dystrophy, Lattice Type Iii
Lattice Corneal Dystrophy, Type Iii	Amyloidosis Corneal
Lattice Corneal Dystrophy Type3	Amyloid Corneal Dystrophy Japanese Type
Dystrophy, Corneal, Gelatinous Drop-Like	Amyloid Of Cornea

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Corneal Dystrophy

Epithelial And Subepithelial Dystrophy

Taeniasis

Beef Tapeworm Infection	Infection By Taeniarhynchus Saginatus
Taenia Saginata Infectious Disease	Taenia Saginata Infection
Pork Tapeworm Infection	Armed Tapeworm Infection
Infection By Taenia Solium	Intestinal Taenia Solium Infection
Pork Tapeworm	Taenia Solium Taeniasis
Adult Pork Tapeworm Infection	Adult Pork Tapeworm
Beef Tapeworm	Infection By Taenia Saginata
Unarmed Tapeworm Infection	Taenia Saginata Taeniasis
Infection Due To Adult Tapeworm Taenia Saginata	Mediocanellata Taenia Infection
Infestation By Taenia Saginata	Infestation By Taenia Mediocanellata

Gastrointestinal Carcinoma

Gastrointestinal Neoplasms

Coenurosis

Coenuriasis

Ovary Leiomyosarcoma

Leiomyosarcoma Of Ovary

Corneal Dystrophy, Reis-Bucklers Type

Reis-Bucklers Corneal Dystrophy	Rbcd
CDRB	Cdb1
Corneal Dystrophy Of Bowman Layer Type I	Geographic Corneal Dystrophy
Granular Corneal Dystrophy Type Iii	Reis-Bucklers' Corneal Dystrophy
Anterior Limiting Membrane Dystrophy Type I	Corneal Dystrophy Of Bowman Layer Type 1
Corneal Dystrophy Of Bowman Layer, Type I	Corneal Dystrophy, Geographic
Granular Corneal Dystrophy, Type Iii	Corneal Dystrophy Reis Bucklers Type
Corneal Dystrophy Geographic	Reis Bucklers Corneal Dystrophy
Reis Bucklers Dystrophy	Anterior Limiting Membrane Dystrophy Type 1
Atypical Granular Corneal Dystrophy	Granular Corneal Dystrophy Type 3
Superficial Granular Corneal Dystrophy	Corneal Dystrophy Of Bowman Layer, Type 1
Dystrophy, Corneal, Reis-Bucklers Type

Corneal Dystrophy, Thiel-Behnke Type

Thiel-Behnke Corneal Dystrophy	Tbcd
CDTB	Cdb2
Corneal Dystrophy Of Bowman Layer Type Ii	Anterior Limiting Membrane Dystrophy Type Ii
Waardenburg-Jonker Corneal Dystrophy	Corneal Dystrophy Of Bowman Layer, Type Ii
Corneal Dystrophy, Honeycomb-Shaped	Corneal Dystrophy Honeycomb-Shaped
Corneal Dystrophy Thiel Behnke Type	Corneal Dystrophy Honeycomb Shaped
Corneal Dystrophy Of The Bowman Layer Type 2	Thiel Behnke Corneal Dystrophy
Anterior Limiting Membrane Dystrophy Type 2	Corneal Dystrophy Of Bowman Layer Type 2
Curly Fiber Corneal Dystrophy	Honeycomb Corneal Dystrophy
Honeycomb-Shaped Corneal Dystrophy	Dystrophy, Corneal, Thiel-Behnke Type

Cysticercosis

Neurocysticercosis	Submacular Cysticercosis
Intestinal Taenia Solium Infection	Pork Tapeworm Infection
Tapeworm Infection: Intestinal Taenia Solum	Tapeworm Infection: Pork
Tenia Solium Infectious Disease	Taeniasis
Tenia Solium Infection	Cysticerciasis Infection Due To Larval Form Of Taenia Solium

Ovarian Carcinosarcoma

Ovarian Malignant Mixed Mullerian Tumor	Mmmt Of The Ovary
Malignant Mixed Mullerian Tumor Of The Ovary	Ovarian Malignant Mixed Epithelial Mesenchymal Tumor
Ovarian Malignant Mesodermal Mixed Tumor	Ovarian Mmmt
Malignant Mixed Müllerian Tumor Of The Ovary	Ovarian Malignant Mixed Müllerian Tumor
Carcinosarcoma Of Ovary

Corneal Deposit

Deposits - Cornea

Granular Corneal Dystrophy

Granular Dystrophy Corneal	Corneal Dystrophies, Hereditary
Hereditary Corneal Dystrophy	Corneal Dystrophy Nos
Familial Hereditary Corneal Degeneration	Hereditary Corneal Opacity

Corneal Dystrophy, Avellino Type

Avellino Corneal Dystrophy	CDA
Combined Granular-Lattice Corneal Dystrophy	Cgd2
Granular Corneal Dystrophy Type 2	Acd
Granular Corneal Dystrophy 2	Corneal Dystrophy Avellino Type
Granular Corneal Dystrophy Type Ii	Granular Corneal Dystrophy, Type Ii
Combined Granular-Lattice Corneal Dystrophies	Granular And Lattice Corneal Dystrophies
Granular-Lattice Corneal Dystrophy	Gcd2
Gcdii	Granular-Lattice Corneal Dystrophy

Macular Dystrophy, Corneal

Macular Corneal Dystrophy	MCD
Corneal Dystrophy, Macular Type	Groenouw Type Ii Corneal Dystrophy
Fehr Corneal Dystrophy	Macular Dystrophy, Corneal Type 1
Mcdc1	Macular Corneal Dystrophy Type Ii
Macular Corneal Dystrophy, Type Ii	Macular Corneal Dystrophy, Type I
Mcdc1, Formerly	Macular Dystrophy, Corneal, 1
Macular Corneal Dystrophy Type 1	Corneal Dystrophy Groenouw Type Ii
Corneal Dystrophy Macular Type	Macular Corneal Dystrophy Type I
Dystrophy, Macular, Corneal

Premature Ovarian Failure 18

POF18	Primary Ovarian Insufficiency 18
Ovarian Failure, Premature, Type 18

Corneal Dystrophy, Band-Shaped

Band Keratopathy

Band-Shaped Keratopathy

Corneal Degeneration

Degenerative Corneal Opacity

Klatskin'S Tumor

Klatskin Tumor	Hilar Cholangiocarcinoma
Perihilar Cholangiocarcinoma	Hilar Cholangiocellular Carcinoma
Klatskin Tumour	Klatskin'S Tumour
Perihilar Extrahepatic Bile Duct Carcinoma	Hilar Cca
Adenocarcinoma Of Hepatic Duct	Klatskin Tumour Of Biliary Tree

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Epithelial-Stromal Tgfbi Dystrophy

Corneal Disease

Corneal Diseases

Corneal Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14152	TACSTD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TACSTD2	VGNC	VGNC:35563
Felis catus	TACSTD2	VGNC	VGNC:80372
Mus musculus	TACSTD2	MGD	MGI:1861606
Macaca mulatta	TACSTD2	VGNC	VGNC:78085
Rattus norvegicus	TACSTD2	RGD	RGD:1359498
Macaca fascicularis	TACSTD2	NCBI	NCBI:102127436
Others	TACSTD2	NCBI

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