DDI1 - DNA damage inducible 1 homolog 1 Gene

Homo sapiens

Gene ID: 414301 | Gene type: protein coding

About DDI1

This gene has 1 transcript (splice variant), 188 orthologues and 4 paralogues.

Summary

Predicted to enable aspartic-type endopeptidase activity. Involved in several processes, including cellular response to hydroxyurea; proteasomal protein catabolic process; and regulation of DNA stability. [provided by Alliance of Genome Resources, Apr 2022]

DDI1 Products(1)

mRNA	Protein	Name
NM_001001711.3	NP_001001711.1	protein DDI1 homolog 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of DNA stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDI1 Protein Structure

ubiquitin

Asp_protease

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

protein DDI1 homolog 1

DDI1, DNA-damage inducible 1, homolog 1

Related Diseases

Diseases

Alias

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Ngly1-Deficiency

Deficiency Of N-Glycanase 1	Ngly1-Cddg
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome	Ngly1 Deficiency
Congenital Disorder Of Deglycosylation	Congenital Disorder Of Glycosylation Type Iv
Congenital Disorder Of Deglycosylation	Cddg
Congenital Disorder Of Glycosylation Type Iv	Cdg1v

Kenny-Caffey Syndrome, Type 2

KCS2	Kenny-Caffey Syndrome Type 2
Autosomal Dominant Kenny-Caffey Syndrome	Kenny Syndrome
Dwarfism, Cortical Thickening Of Tubular Bones, And Transient Hypocalcemia	Dwarfism, Cortical Thickening Of Tubular Bones And Transient Hypocalcemia
Kenny-Caffey Syndrome, Autosomal Dominant	Kenny-Caffey Syndrome 2
Dwarfism With Cortical Thickening Of Tubular Bones And Transient Hypocalcemia	Kenny-Caffey Syndrome

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Median Arcuate Ligament Syndrome

Celiac Artery Compression Syndrome	Dunbar Syndrome
Mals	Harjola-Marable Syndrome
Marable'S Syndrome	Celiac Axis Syndrome

Childhood Germ Cell Cancer

Pediatric Germ Cell Tumor	Paediatric Germ Cell Cancer
Paediatric Germ Cell Neoplasm	Pediatric Germ Cell Cancer
Pediatric Germ Cell Neoplasm

Kenny-Caffey Syndrome

Kenny Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03611	DDI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DDI1	VGNC	VGNC:27945
Mus musculus	DDI1	MGD	MGI:1919079
Rattus norvegicus	DDI1	RGD	RGD:1559430
Canis familiaris	DDI1	VGNC	VGNC:39834
Felis catus	DDI1	VGNC	VGNC:105842
Macaca mulatta	DDI1	VGNC	VGNC:100923

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