2. Gene
  3. DEFB103A - defensin beta 103A Gene

DEFB103A - defensin beta 103A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BD-3; HBD3; HBP3; DEFB3; HBP-3; DEFB-3; DEFB103

Gene ID: 414325 | Gene type: protein coding

About DEFB103A

This gene has 1 transcript (splice variant), 1 gene allele, 94 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

Defensins form a family of microbicidal and cytotoxic Peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an Antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]

DEFB103A Products(1)

mRNA Protein Name
NM_001081551.4 NP_001075020.1 beta-defensin 103 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
11085990 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
11085990 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
15625724 GOA
involved in defense response to Gram-positive bacterium IEP
IEP: Inferred from expression pattern
11085990 GOA
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
21115716 GOA
involved in killing by host of symbiont cells IDA
IDA: Inferred from direct assay
16436752 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
11085990 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
21115716 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEFB103A Protein Structure

Defensin_beta

Defensin_beta: Beta defensin (30 - 64)

  • 0
  • 67 a.a.
Protein Preferred Names Protein Names

beta-defensin 103

beta-defensin 3

DEFB103A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DEFB103A P81534 SPATA31A7 Homo sapiens Q8IWB4
Validated Y2H
32296183
Intra
DEFB103A P81534 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
DEFB103A P81534 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 ODF4 Homo sapiens Q2M2E3
Validated Y2H
32296183
Intra
DEFB103A P81534 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
DEFB103A P81534 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
DEFB103A P81534 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
DEFB103A P81534 B3GALT5 Homo sapiens Q9Y2C3
Validated Y2H
32296183
Intra
DEFB103A P81534 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
DEFB103A P81534 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
DEFB103A P81534 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
DEFB103A P81534 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
DEFB103A P81534 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
DEFB103A P81534 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
DEFB103A P81534 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
DEFB103A P81534 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
DEFB103A P81534 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
DEFB103A P81534 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
DEFB103A P81534 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DEFB103A Proteins

Cat. No. Product Name Accession Purity
HY-P7137 BD-3 Protein, Human P81534 (G23-K67) ≥95%

Related Diseases

Diseases Alias
Ileitis

Crohn'S Ileitis
Cardiomyopathy, Familial Hypertrophic, 12

Hypertrophic Cardiomyopathy 12

CMH12

Cardiomyopathy, Hypertrophic, 12

Cardiomyopathy Familial Hypertrophic 12

Cardiomyopathy, Familial Hypertrophic 12

Cardiomyopathy, Hypertrophic, Familial, Type 12
Cardiomyopathy, Familial Hypertrophic, 6

Hypertrophic Cardiomyopathy 6

CMH6

Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome

Cardiomyopathy, Familial Hypertrophic 6

Cardiomyopathy, Hypertrophic 6

Cardiomyopathy, Hypertrophic, Familial, Type 6
Eczema Herpeticum

Herpes Simplex Dermatitis

Herpes Simplex Eyelid Dermatitis

Kaposi Varicelliform Eruption

Herpes Simplex Dermatitis Of Eyelid

Herpes Simplex Virus Dermatitis

Herpes Simplex Virus Eyelid Dermatitis
Denture Stomatitis

Stomatitis, Denture

Denture Sore Mouth
Crohn'S Colitis

Crohn Disease
Oral Candidiasis

Thrush

Candidiasis Of Mouth

Oral Moniliasis

Thrush, Oral

Candidiasis, Oral

Oral Thrush

Candidiasis

Equine Thrush
Vaginal Disease

Vaginal Diseases
Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous

Cmc

Candidiasis Chronic Mucocutaneous
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03679 DEFB103A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DEFB103A MGD MGI:2675345
Rattus norvegicus DEFB103A RGD RGD:1561378