2. Gene
  3. ERGIC3 - ERGIC and golgi 3 Gene

ERGIC3 - ERGIC and golgi 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Erv46; CGI-54; C2orf47; PRO0989; C20orf47; NY-BR-84; SDBCAG84; dJ477O4.2

Gene ID: 51614 | Gene type: protein coding

About ERGIC3

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,542,078-35,557,634 (from NCBI)

This gene has 19 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 113.7), testis (RPKM 112.2) and 25 other tissues.

Summary

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ERGIC3 Products(2)

mRNA Protein Name
NM_015966.3 NP_057050.1 endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform b
NM_198398.2 NP_938408.1 endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15308636 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
31142615 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: Inferred from mutant phenotype
31142615 GOA
Cellular Component GO Annotation Evidence Reference Source
part of retrograde transporter complex, Golgi to ER IPI
IPI: Inferred from physical interaction
31142615 GOA
part of transporter complex IPI
IPI: Inferred from physical interaction
31142615 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERGIC3 Protein Structure

ERGIC_N

ERGIC_N: Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) (6 - 101)

COPIIcoated_ERV

COPIIcoated_ERV: Endoplasmic reticulum vesicle transporter (145 - 363)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum-Golgi intermediate compartment protein 3

endoplasmic reticulum-localized protein ERp43

ERGIC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra ERGIC3 Q9Y282 MARCHF2 Homo sapiens Q9P0N8
Anti Tag CoIP
31142615
Intra ERGIC3 Q9Y282 HP Homo sapiens P00738
Anti Bait CoIP
31142615
Intra ERGIC3 Q9Y282 SFXN5 Homo sapiens Q8TD22
Anti Tag CoIP
33961781
Intra ERGIC3 Q9Y282 VMP1 Homo sapiens Q96GC9
Anti Tag CoIP
33961781
Intra ERGIC3 Q9Y282 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 UBIAD1 Homo sapiens Q9Y5Z9
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 TMEM222 Homo sapiens Q9H0R3
Y2H Prey Pooling
32296183
Intra ERGIC3 Q9Y282 PLLP Homo sapiens Q9Y342
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 ERGIC2 Homo sapiens Q96RQ1
Anti Tag CoIP
31142615
Intra ERGIC3 Q9Y282 ERGIC2 Homo sapiens Q96RQ1
Anti Tag CoIP
33961781
Intra ERGIC3 Q9Y282 UNC50 Homo sapiens Q53HI1
Y2H Array
32296183
Intra ERGIC3 Q9Y282 ERGIC1 Homo sapiens Q969X5
Anti Tag CoIP
31142615
Intra ERGIC3 Q9Y282 ERGIC1 Homo sapiens Q969X5
IF
15308636
Intra ERGIC3 Q9Y282 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra ERGIC3 Q9Y282 SERPINA1 Homo sapiens P01009
Anti Bait CoIP
31142615
Intra ERGIC3 Q9Y282 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1
Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

Atr Syndrome Linked To Chromosome 16

Atr Syndrome, Deletion Type

Atr-16 Syndrome

Alpha Thalassemia-Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy

Bafme

Benign Adult Familial Myoclonic Epilepsy

Fame

Familial Cortical Myoclonic Tremor And Epilepsy

Fcmte

Adcme

Autosomal Dominant Cortical Myoclonus And Epilepsy

Fam

Epilepsy, Myoclonic, Familial Adult

Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16915 RPR-260243 Activator 99.91% Unkown
HY-RS04494 ERGIC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ERGIC3 VGNC VGNC:72274
Rattus norvegicus ERGIC3 RGD RGD:1308144
Mus musculus ERGIC3 MGD MGI:1913616
Bos taurus ERGIC3 VGNC VGNC:28580
Canis familiaris ERGIC3 VGNC VGNC:40452
Felis catus ERGIC3 VGNC VGNC:61941