MEP1A - meprin A subunit alpha Gene

Homo sapiens

Also known as PPHA

Gene ID: 4224 | Gene type: protein coding

About MEP1A

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:46,793,389-46,845,984 (from NCBI)

This gene has 4 transcripts (splice variants), 40 orthologues and 35 paralogues. Biased expression in small intestine (RPKM 216.8), duodenum (RPKM 122.1) and 1 other tissue.

Summary

Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular exosome. Part of meprin A complex. [provided by Alliance of Genome Resources, Apr 2022]

MEP1A Products(1)

mRNA	Protein	Name
NM_005588.3	NP_005579.2	meprin A subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metallodipeptidase activity	IDA IDA: Inferred from direct assay	22923609	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	22923609	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9288916	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in epidermal growth factor receptor ligand maturation	IDA IDA: Inferred from direct assay	22923609	GOA
involved in signaling receptor ligand precursor processing	IDA IDA: Inferred from direct assay	22923609	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of meprin A complex	IDA IDA: Inferred from direct assay	9288916	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	22923609	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEP1A Protein Structure

Astacin

MAM

MATH

EGF

0
200
400
600
746 a.a.

Protein Preferred Names

Protein Names

meprin A subunit alpha

N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha

MEP1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MEP1A	Q16819	MMP9	Homo sapiens	P14780	Zymography	23123160

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MEP1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77083	Meprin alpha/MEP1A Protein, Human (HEK293, His)	Q16819/NP_005579.2 (V22-Q601)	≥95%

Related Diseases

Diseases

Alias

Colorado Tick Fever

Mountain Tick Fever	Tick Fever, American Mountain
American Mountain Fever	Colorado Tick Encephalitis
Colorado Tick-Borne Disease	Mountain Fever
American Mountain Tick Fever	Colorado Tick-Borne Fever
Colorado Tick Fever Virus	Non-Exanthematous Tick Fever

Powassan Encephalitis

Powassan Encephalitis Virus Infection

Anisakiasis

Infection By Anisakis Larva	Anisakis Infection
Pseudoterranova Infection	Anisakiasis Due To Anisakis Simplex
Anisakiasis Due To Pseudoterranova Decipiens	Anisakis Infestation
Infection Due To Anisakis Larvae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08336	MEP1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MEP1A	MGD	MGI:96963
Canis familiaris	MEP1A	VGNC	VGNC:43159
Felis catus	MEP1A	VGNC	VGNC:102461
Bos taurus	MEP1A	VGNC	VGNC:31388
Macaca mulatta	MEP1A	VGNC	VGNC:74704
Rattus norvegicus	MEP1A	RGD	RGD:3080
Others	MEP1A	NCBI

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