2. Gene
  3. ASTL - astacin like metalloendopeptidase Gene

ASTL - astacin like metalloendopeptidase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAS1B; OOMD11

Gene ID: 431705 | Gene type: protein coding

About ASTL

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,122,818-96,138,564 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues, 35 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 1.1), skin (RPKM 0.2) and 10 other tissues.

Summary

Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ASTL Products(1)

mRNA Protein Name
NM_001002036.4 NP_001002036.3 astacin-like metalloendopeptidase precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASTL Protein Structure

Astacin

Astacin: Astacin (Peptidase family M12A) (103 - 282)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

astacin-like metalloendopeptidase

ZP2-proteinase

Related Diseases

Diseases Alias
Oocyte Maturation Defect 11

OOMD11
Colorado Tick Fever

Mountain Tick Fever

Tick Fever, American Mountain

American Mountain Fever

Colorado Tick Encephalitis

Colorado Tick-Borne Disease

Mountain Fever

American Mountain Tick Fever

Colorado Tick-Borne Fever

Colorado Tick Fever Virus

Non-Exanthematous Tick Fever
Powassan Encephalitis

Powassan Encephalitis Virus Infection
Anisakiasis

Infection By Anisakis Larva

Anisakis Infection

Pseudoterranova Infection

Anisakiasis Due To Anisakis Simplex

Anisakiasis Due To Pseudoterranova Decipiens

Anisakis Infestation

Infection Due To Anisakis Larvae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01111 ASTL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ASTL RGD RGD:1562279
Mus musculus ASTL MGD MGI:3046414
Macaca mulatta ASTL VGNC VGNC:106129
Felis catus ASTL VGNC VGNC:59982
Bos taurus ASTL VGNC VGNC:26226
Others ASTL NCBI