MMP16 - matrix metallopeptidase 16 Gene

Homo sapiens

Also known as MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP

Gene ID: 4325 | Gene type: protein coding

About MMP16

Cytogenetic location: 8q21.3 Genomic coordinates (GRCh38): 8:88,032,011-88,327,483 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues and 23 paralogues. Biased expression in brain (RPKM 3.8), gall bladder (RPKM 1.9) and 12 other tissues.

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

MMP16 Products(1)

mRNA	Protein	Name
NM_005941.5	NP_005932.2	matrix metalloproteinase-16 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metalloaminopeptidase activity	IDA IDA: Inferred from direct assay	24970228	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	27229514	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	27229514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein processing	IDA IDA: Inferred from direct assay	27229514	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	24970228	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	7559440	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP16 Protein Structure

PG_binding_1

Peptidase_M10

Hemopexin

DUF3377

0
100
200
300
400
500
607 a.a.

Protein Preferred Names

Protein Names

matrix metalloproteinase-16

MMP-16

Recombinant MMP16 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79097	MMP-16 Protein, Human (I152N, His)	P51512 (A32-G291, I152N)	≥95%

Related Diseases

Diseases

Alias

Seminoma

Seminoma, Pure

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Supraglottis Cancer

Malignant Tumor Of Supraglottis	Supraglottis
Ca Larynx - Supraglottis	Malignant Neoplasm Of Extrinsic Larynx
Malignant Neoplasm Of Supraglottis	Malignant Supraglottic Tumor
Neoplasm Of Supraglottis

Winchester Syndrome

WNCHRS	Winchester Disease
Winchester-Grossman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08532	MMP16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MMP16	VGNC	VGNC:43278
Macaca mulatta	MMP16	VGNC	VGNC:74894
Mus musculus	MMP16	MGD	MGI:1276107
Rattus norvegicus	MMP16	RGD	RGD:620199
Felis catus	MMP16	VGNC	VGNC:68284
Bos taurus	MMP16	VGNC	VGNC:31521
Others	MMP16	NCBI

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