MNT - MAX network transcriptional repressor Gene

Homo sapiens

Also known as ROX; MAD6; MXD6; bHLHd3; lncRNA-HAL

Gene ID: 4335 | Gene type: protein coding

About MNT

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,384,073-2,401,060 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 4.9), bone marrow (RPKM 4.7) and 25 other tissues.

Summary

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

MNT Products(1)

mRNA	Protein	Name
NM_020310.3	NP_064706.1	max-binding protein MNT

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9184233	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	9598315	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9184233	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9184233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9184233	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9184233	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9598315	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MNT Protein Structure

HLH

0
100
200
300
400
500
582 a.a.

Protein Preferred Names

Protein Names

max-binding protein MNT

MAX binding protein

MNT Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MNT	Q99583	MAX	Homo sapiens	P61244	Y2H	9184233
Intra	MNT	Q99583	MAX	Homo sapiens	P61244	Pull Down	9184233
Intra	MNT	Q99583	MAX	Homo sapiens	P61244	Anti Bait CoIP	9184233
Intra	MNT	Q99583	TPR	Homo sapiens	P12270	Crosslink	30021884
Intra	MNT	Q99583	SMS	Homo sapiens	P52788	Crosslink	30021884
Intra	MNT	Q99583	MNT	Homo sapiens	Q99583	Y2H	9184233
Intra	MNT	Q99583	MNT	Homo sapiens	Q99583	Pull Down	9184233
Intra	MNT	Q99583	ITGB1	Homo sapiens	P05556	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wolfram Syndrome 2

WFS2

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2983	Cajanin	Inhibitor	99.96%	Unkown
HY-RS08570	MNT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MNT	VGNC	VGNC:74907
Mus musculus	MNT	MGD	MGI:109150
Bos taurus	MNT	VGNC	VGNC:31540
Rattus norvegicus	MNT	RGD	RGD:1308683
Canis familiaris	MNT	VGNC	VGNC:43298
Felis catus	MNT	VGNC	VGNC:68296
Others	MNT	NCBI

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