NRARP - NOTCH regulated ankyrin repeat protein Gene

Homo sapiens

Gene ID: 441478 | Gene type: protein coding

About NRARP

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:137,299,631-137,302,271 (from NCBI)

This gene has 1 transcript (splice variant), 187 orthologues and 2 paralogues.

Summary

Involved in Notch signaling pathway. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of canonical Wnt signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]

NRARP Products(1)

mRNA	Protein	Name
NM_001004354.3	NP_001004354.1	notch-regulated ankyrin repeat-containing protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	25985737	GOA
acts upstream of or within negative regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	19154719	GOA
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	19154719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NRARP Protein Structure

Ank_2

0
100
114 a.a.

Protein Preferred Names

Protein Names

notch-regulated ankyrin repeat-containing protein

NRARP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NRARP	Q7Z6K4	GTF2E1	Homo sapiens	P29083	Y2H Prey Pooling	32296183
Intra	NRARP	Q7Z6K4	GTF2E1	Homo sapiens	P29083	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spondylocostal Dysostosis

Jarcho-Levin Syndrome	Costovertebral Dysplasia
Spondylothoracic Dysostosis	Spondylothoracic Dysplasia
Scdo	Dysostosis, Spondylocostal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09557	NRARP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NRARP	VGNC	VGNC:32252
Macaca mulatta	NRARP	VGNC	VGNC:75498
Felis catus	NRARP	VGNC	VGNC:102957
Rattus norvegicus	NRARP	RGD	RGD:1591939
Mus musculus	NRARP	MGD	MGI:1914372
Canis familiaris	NRARP	VGNC	VGNC:43958

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