2. Gene
  3. MYO1B - myosin IB Gene

MYO1B - myosin IB Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MMIa; myr1; MYH-1c; MMI-alpha

Gene ID: 4430 | Gene type: protein coding

About MYO1B

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,245,404-191,425,386 (from NCBI)

This gene has 15 transcripts (splice variants), 211 orthologues and 43 paralogues. Broad expression in liver (RPKM 53.1), lung (RPKM 45.2) and 23 other tissues.

Summary

Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Involved in actin filament organization and post-Golgi vesicle-mediated transport. Located in several cellular components, including actin filament; endosome; and perinuclear region of cytoplasm. Colocalizes with trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

MYO1B Products(5)

mRNA Protein Name
NM_001130158.3 NP_001123630.1 unconventional myosin-Ib isoform 1
NM_001161819.3 NP_001155291.1 unconventional myosin-Ib isoform 1
NM_001330237.2 NP_001317166.1 unconventional myosin-Ib isoform 4
NM_001330238.2 NP_001317167.1 unconventional myosin-Ib isoform 5
NM_012223.5 NP_036355.2 unconventional myosin-Ib isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
21666684 GOA
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
21666684 GOA
enables microfilament motor activity IMP
IMP: Inferred from mutant phenotype
21666684 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
21666684 GOA
involved in post-Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
21666684 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin filament IDA
IDA: Inferred from direct assay
16219689 GOA
located in early endosome IDA
IDA: Inferred from direct assay
16219689 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
16219689 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21666684 GOA
colocalizes with trans-Golgi network membrane IDA
IDA: Inferred from direct assay
21666684 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO1B Protein Structure

Myosin_head

Myosin_head: Myosin head (motor domain) (18 - 688)

IQ

IQ: IQ calmodulin-binding motif (707 - 724)

IQ

IQ: IQ calmodulin-binding motif (752 - 770)

Myosin_TH1

Myosin_TH1: Unconventional myosin tail, actin- and lipid-binding (941 - 1131)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1136 a.a.
Protein Preferred Names Protein Names

unconventional myosin-Ib

MYO1B variant protein

MYO1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MYO1B O43795 SUOX Homo sapiens P51687
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Deafness, Autosomal Dominant 48

DFNA48

Autosomal Dominant Nonsyndromic Deafness 48

Autosomal Dominant Deafness 48

Deafness, Autosomal Dominant, 48

Deafness Autosomal Dominant Due To Mutation In Myo1a

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 48

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 48

Deafness, Autosomal Dominant, Type 48
Scrotum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Scrotum

Scrotal Squamous Cell Carcinoma
Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis

Acanthamoeba Encephalitis

Acanthamoeba Granulomatous Encephalitis

Granulomatous Amebic Encephalitis Due To Acanthamoeba
Primary Amebic Meningoencephalitis

Pam

Naegleria Fowleri Infection

Meningoencephalitis Caused By Naegleria Fowleri

Primary Amoebic Meningoencephalitis
Scrotal Carcinoma

Carcinoma Of Scrotum

Malignant Neoplasm Of Scrotum

Neoplasm Of Scrotum
Amebiasis

Amoebiasis

Entamoebiasis

Chronic Intestinal Amebiasis

Amoebiasis, Unspecified

Amebic Colitis

Amoebic Enteritis

Infection Due To Entamoeba Histolytica

Amoebic Infection

Disease Due To Endamoebidae

Amoebiasis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08938 MYO1B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MYO1B MGD MGI:107752
Bos taurus MYO1B VGNC VGNC:31817
Canis familiaris MYO1B VGNC VGNC:43561
Macaca mulatta MYO1B VGNC VGNC:75111
Rattus norvegicus MYO1B RGD RGD:70994
Felis catus MYO1B VGNC VGNC:68389