MSRA - methionine sulfoxide reductase A Gene

Homo sapiens

Also known as PMSR

Gene ID: 4482 | Gene type: protein coding

About MSRA

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:10,054,292-10,428,891 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 109 orthologues and 3 paralogues. Broad expression in kidney (RPKM 12.0), bone marrow (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

MSRA Products(4)

mRNA	Protein	Name
NM_001135670.3	NP_001129142.1	mitochondrial peptide methionine sulfoxide reductase isoform b
NM_001135671.3	NP_001129143.1	mitochondrial peptide methionine sulfoxide reductase isoform c
NM_001199729.3	NP_001186658.1	mitochondrial peptide methionine sulfoxide reductase isoform d
NM_012331.5	NP_036463.1	mitochondrial peptide methionine sulfoxide reductase isoform a precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSRA Protein Structure

PMSR

0
100
200
235 a.a.

Protein Preferred Names

Protein Names

mitochondrial peptide methionine sulfoxide reductase

cytosolic methionine-S-sulfoxide reductase

MSRA Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSRA	Q9UJ68	UBASH3B	Homo sapiens	Q8TF42	Anti Tag CoIP	33961781
Intra	MSRA	Q9UJ68	FBXL3	Homo sapiens	Q9UKT7	Validated Y2H	32296183
Intra	MSRA	Q9UJ68	HPCAL4	Homo sapiens	Q9UM19	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2188	S-Methyl-L-cysteine		≥98.0%	Unkown
HY-D1256	Msr-blue		99.38%	Unkown
HY-RS08725	MSRA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MSRA	VGNC	VGNC:31705
Mus musculus	MSRA	MGD	MGI:106916
Rattus norvegicus	MSRA	RGD	RGD:70979
Macaca mulatta	MSRA	VGNC	VGNC:74940
Felis catus	MSRA	VGNC	VGNC:68330
Canis familiaris	MSRA	VGNC	VGNC:43449

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