MT1B - metallothionein 1B Gene

Homo sapiens

Also known as MT1; MTP; MT1Q; MT-1B; MT-IB

Gene ID: 4490 | Gene type: protein coding

About MT1B

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,651,886-56,653,204 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 11 paralogues. Biased expression in liver (RPKM 1.6), duodenum (RPKM 0.4) and 1 other tissue.

Summary

The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

MT1B Products(1)

mRNA	Protein	Name
NM_005947.3	NP_005938.1	metallothionein-1B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	11168427	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1B Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names

Protein Names

metallothionein-1B

metallothionein 1B (functional)

MT1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT1B	P07438	KRTAP5-2	Homo sapiens	Q701N4	Validated Y2H	32296183
Intra	MT1B	P07438	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	MT1B	P07438	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	MT1B	P07438	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	MT1B	P07438	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	MT1B	P07438	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	MT1B	P07438	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	MT1B	P07438	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	MT1B	P07438	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	MT1B	P07438	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	MT1B	P07438	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	MT1B	P07438	KRTAP10-6	Homo sapiens	P60371	Validated Y2H	32296183
Intra	MT1B	P07438	SMCP	Homo sapiens	P49901	Validated Y2H	32296183
Intra	MT1B	P07438	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	MT1B	P07438	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08736	MT1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT1B	MGD	MGI:97171
Others	MT1B	NCBI

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