2. Gene
  3. SMCP - sperm mitochondria associated cysteine rich protein Gene

SMCP - sperm mitochondria associated cysteine rich protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MCS; MCSP; HSMCSGEN1

Gene ID: 4184 | Gene type: protein coding

About SMCP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,878,322-152,885,047 (from NCBI)

This gene has 1 transcript (splice variant) and 29 orthologues. Restricted expression toward testis (RPKM 221.5).

Summary

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

SMCP Products(1)

mRNA Protein Name
NM_030663.3 NP_109588.2 sperm mitochondrial-associated cysteine-rich protein
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm mitochondrial-associated cysteine-rich protein

testicular tissue protein Li 119

SMCP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SMCP P49901 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP10-8 Homo sapiens P60410
Validated Y2H
32296183
Intra SMCP P49901 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra SMCP P49901 KRTAP10-9 Homo sapiens P60411
Validated Y2H
32296183
Intra SMCP P49901 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra SMCP P49901 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra SMCP P49901 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP10-5 Homo sapiens P60370
Y2H Array
25416956
Intra SMCP P49901 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra SMCP P49901 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra SMCP P49901 KRTAP10-7 Homo sapiens P60409
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
32296183
Intra SMCP P49901 KRTAP12-4 Homo sapiens P60329
Validated Y2H
32296183
Intra SMCP P49901 KRTAP9-4 Homo sapiens Q9BYQ2
Y2H Array
25416956
Intra SMCP P49901 KRTAP9-4 Homo sapiens Q9BYQ2
Validated Y2H
25416956
Intra SMCP P49901 KRTAP12-1 Homo sapiens P59990
Validated Y2H
32296183
Intra SMCP P49901 KRTAP10-11 Homo sapiens P60412
Validated Y2H
32296183
Intra SMCP P49901 LCE1B Homo sapiens Q5T7P3
Validated Y2H
32296183
Intra SMCP P49901 LCE4A Homo sapiens Q5TA78
Validated Y2H
32296183
Intra SMCP P49901 LCE4A Homo sapiens Q5TA78
Validated Y2H
25416956
Intra SMCP P49901 LCE4A Homo sapiens Q5TA78
Y2H Prey Pooling
25416956
Intra SMCP P49901 LCE4A Homo sapiens Q5TA78
Y2H Array
25416956
Intra SMCP P49901 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
Intra SMCP P49901 VASN Homo sapiens Q6EMK4
Validated Y2H
32296183
Intra SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
32296183
Intra SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Array
25416956
Intra SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP5-6 Homo sapiens Q6L8G9
Validated Y2H
25416956
Intra SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
25416956
Intra SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-11 Homo sapiens Q9BYQ6
Y2H Array
25416956
Intra SMCP P49901 KRTAP4-7 Homo sapiens Q9BYR0
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP4-7 Homo sapiens Q9BYR0
Y2H Array
25416956
Intra SMCP P49901 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra SMCP P49901 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra SMCP P49901 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
25416956
Intra SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra SMCP P49901 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra SMCP P49901 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra SMCP P49901 SLC39A7 Homo sapiens Q92504
Validated Y2H
32296183
Intra SMCP P49901 KRTAP1-5 Homo sapiens Q9BYS1
Validated Y2H
32296183
Intra SMCP P49901 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Array
32296183
Intra SMCP P49901 LCE1D Homo sapiens Q5T752
Validated Y2H
32296183
Intra SMCP P49901 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra SMCP P49901 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra SMCP P49901 LCE1E Homo sapiens Q5T753
Validated Y2H
32296183
Intra SMCP P49901 LCE5A Homo sapiens Q5TCM9
Validated Y2H
32296183
Intra SMCP P49901 PCSK5 Homo sapiens Q92824-2
Validated Y2H
32296183
Intra SMCP P49901 LCE1F Homo sapiens Q5T754
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-4 Homo sapiens Q9BYR3
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP4-4 Homo sapiens Q9BYR3
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-4 Homo sapiens Q9BYR3
Y2H Array
32296183
Intra SMCP P49901 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP5-2 Homo sapiens Q701N4
Validated Y2H
32296183
Intra SMCP P49901 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra SMCP P49901 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Array
32296183
Intra SMCP P49901 KRTAP9-8 Homo sapiens Q9BYQ0
Validated Y2H
32296183
Intra SMCP P49901 KRTAP9-8 Homo sapiens Q9BYQ0
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra SMCP P49901 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra SMCP P49901 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra SMCP P49901 LCE1A Homo sapiens Q5T7P2
Validated Y2H
32296183
Intra SMCP P49901 KRTAP5-4 Homo sapiens Q6L8H1
Validated Y2H
32296183
Intra SMCP P49901 LCE2C Homo sapiens Q5TA81
Validated Y2H
32296183
Intra SMCP P49901 KRTAP5-3 Homo sapiens Q6L8H2
Validated Y2H
32296183
Intra SMCP P49901 LCE3B Homo sapiens Q5TA77
Validated Y2H
32296183
Intra SMCP P49901 GUCD1 Homo sapiens Q96NT3-2
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-5 Homo sapiens Q9BYR2
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-5 Homo sapiens Q9BYR2
Y2H Array
32296183
Intra SMCP P49901 KRTAP5-11 Homo sapiens Q6L8G4
Validated Y2H
32296183
Intra SMCP P49901 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra SMCP P49901 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra SMCP P49901 MACO1 Homo sapiens Q8N5G2
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP4-1 Homo sapiens Q9BYQ7
Y2H Array
32296183
Intra SMCP P49901 DYNLL1 Homo sapiens P63167
Y2H Array
32296183
Intra SMCP P49901 DYNLL1 Homo sapiens P63167
Validated Y2H
32296183
Intra SMCP P49901 DYNLL1 Homo sapiens P63167
Y2H Prey Pooling
32296183
Intra SMCP P49901 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra SMCP P49901 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra SMCP P49901 MT1M Homo sapiens Q8N339
Validated Y2H
32296183
Intra SMCP P49901 RGS17 Homo sapiens Q9UGC6
Validated Y2H
25416956
Intra SMCP P49901 RGS17 Homo sapiens Q9UGC6
Y2H Array
25416956
Intra SMCP P49901 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra SMCP P49901 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra SMCP P49901 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra SMCP P49901 PPP1R27 Homo sapiens Q86WC6
Validated Y2H
32296183
Intra SMCP P49901 TRIM42 Homo sapiens Q8IWZ5
Validated Y2H
32296183
Intra SMCP P49901 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra SMCP P49901 UBL5 Homo sapiens Q9BZL1
Validated Y2H
32296183
Intra SMCP P49901 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
Intra SMCP P49901 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra SMCP P49901 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
25416956
Intra SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Pooling
16189514
Intra SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
32296183
Intra SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
32296183
Intra SMCP P49901 DYNLL2 Homo sapiens Q96FJ2
Y2H Prey Pooling
32296183
Intra SMCP P49901 DYNLL2 Homo sapiens Q96FJ2
Validated Y2H
32296183
Intra SMCP P49901 DYNLL2 Homo sapiens Q96FJ2
Y2H Array
32296183
Intra SMCP P49901 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra SMCP P49901 LCE3A Homo sapiens Q5TA76
Validated Y2H
32296183
Intra SMCP P49901 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra SMCP P49901 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra SMCP P49901 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra SMCP P49901 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra SMCP P49901 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra SMCP P49901 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra SMCP P49901 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Intra SMCP P49901 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 21

SPGF21
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Corneal Dystrophy, Subepithelial Mucinous

Subepithelial Mucinous Corneal Dystrophy

SMCD
Infertility
Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13427 SMCP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SMCP RGD RGD:3069
Canis familiaris SMCP VGNC VGNC:46552
Mus musculus SMCP MGD MGI:96945
Macaca mulatta SMCP VGNC VGNC:77816
Bos taurus SMCP VGNC VGNC:59191