SMCP - sperm mitochondria associated cysteine rich protein Gene

Homo sapiens

Also known as MCS; MCSP; HSMCSGEN1

Gene ID: 4184 | Gene type: protein coding

About SMCP

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,878,322-152,885,047 (from NCBI)

This gene has 1 transcript (splice variant) and 29 orthologues. Restricted expression toward testis (RPKM 221.5).

Summary

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

SMCP Products(1)

mRNA	Protein	Name
NM_030663.3	NP_109588.2	sperm mitochondrial-associated cysteine-rich protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sperm mitochondrial-associated cysteine-rich protein

testicular tissue protein Li 119

SMCP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SMCP	P49901	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP10-5	Homo sapiens	P60370	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	SMCP	P49901	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP12-4	Homo sapiens	P60329	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP9-4	Homo sapiens	Q9BYQ2	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP9-4	Homo sapiens	Q9BYQ2	Validated Y2H	25416956
Intra	SMCP	P49901	KRTAP12-1	Homo sapiens	P59990	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP10-11	Homo sapiens	P60412	Validated Y2H	32296183
Intra	SMCP	P49901	LCE1B	Homo sapiens	Q5T7P3	Validated Y2H	32296183
Intra	SMCP	P49901	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	32296183
Intra	SMCP	P49901	LCE4A	Homo sapiens	Q5TA78	Validated Y2H	25416956
Intra	SMCP	P49901	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	LCE4A	Homo sapiens	Q5TA78	Y2H Array	25416956
Intra	SMCP	P49901	LCE2D	Homo sapiens	Q5TA82	Validated Y2H	32296183
Intra	SMCP	P49901	VASN	Homo sapiens	Q6EMK4	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP5-6	Homo sapiens	Q6L8G9	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP5-6	Homo sapiens	Q6L8G9	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP5-6	Homo sapiens	Q6L8G9	Validated Y2H	25416956
Intra	SMCP	P49901	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	25416956
Intra	SMCP	P49901	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP4-11	Homo sapiens	Q9BYQ6	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-11	Homo sapiens	Q9BYQ6	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP4-7	Homo sapiens	Q9BYR0	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP4-7	Homo sapiens	Q9BYR0	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	25416956
Intra	SMCP	P49901	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	SMCP	P49901	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	SLC39A7	Homo sapiens	Q92504	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Array	32296183
Intra	SMCP	P49901	LCE1D	Homo sapiens	Q5T752	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	LCE1E	Homo sapiens	Q5T753	Validated Y2H	32296183
Intra	SMCP	P49901	LCE5A	Homo sapiens	Q5TCM9	Validated Y2H	32296183
Intra	SMCP	P49901	PCSK5	Homo sapiens	Q92824-2	Validated Y2H	32296183
Intra	SMCP	P49901	LCE1F	Homo sapiens	Q5T754	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-4	Homo sapiens	Q9BYR3	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP4-4	Homo sapiens	Q9BYR3	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-4	Homo sapiens	Q9BYR3	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP5-2	Homo sapiens	Q701N4	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP5-2	Homo sapiens	Q701N4	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP5-2	Homo sapiens	Q701N4	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	LCE1A	Homo sapiens	Q5T7P2	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP5-4	Homo sapiens	Q6L8H1	Validated Y2H	32296183
Intra	SMCP	P49901	LCE2C	Homo sapiens	Q5TA81	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP5-3	Homo sapiens	Q6L8H2	Validated Y2H	32296183
Intra	SMCP	P49901	LCE3B	Homo sapiens	Q5TA77	Validated Y2H	32296183
Intra	SMCP	P49901	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-5	Homo sapiens	Q9BYR2	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-5	Homo sapiens	Q9BYR2	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP5-11	Homo sapiens	Q6L8G4	Validated Y2H	32296183
Intra	SMCP	P49901	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	SMCP	P49901	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	MACO1	Homo sapiens	Q8N5G2	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-1	Homo sapiens	Q9BYQ7	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP4-1	Homo sapiens	Q9BYQ7	Y2H Array	32296183
Intra	SMCP	P49901	DYNLL1	Homo sapiens	P63167	Y2H Array	32296183
Intra	SMCP	P49901	DYNLL1	Homo sapiens	P63167	Validated Y2H	32296183
Intra	SMCP	P49901	DYNLL1	Homo sapiens	P63167	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	SMCP	P49901	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	MT1M	Homo sapiens	Q8N339	Validated Y2H	32296183
Intra	SMCP	P49901	RGS17	Homo sapiens	Q9UGC6	Validated Y2H	25416956
Intra	SMCP	P49901	RGS17	Homo sapiens	Q9UGC6	Y2H Array	25416956
Intra	SMCP	P49901	RGS17	Homo sapiens	Q9UGC6	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	SMCP	P49901	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	SMCP	P49901	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	SMCP	P49901	PPP1R27	Homo sapiens	Q86WC6	Validated Y2H	32296183
Intra	SMCP	P49901	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	32296183
Intra	SMCP	P49901	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	SMCP	P49901	UBL5	Homo sapiens	Q9BZL1	Validated Y2H	32296183
Intra	SMCP	P49901	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183
Intra	SMCP	P49901	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	SMCP	P49901	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	SMCP	P49901	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	25416956
Intra	SMCP	P49901	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Pooling	16189514
Intra	SMCP	P49901	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
Intra	SMCP	P49901	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	32296183
Intra	SMCP	P49901	DYNLL2	Homo sapiens	Q96FJ2	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	DYNLL2	Homo sapiens	Q96FJ2	Validated Y2H	32296183
Intra	SMCP	P49901	DYNLL2	Homo sapiens	Q96FJ2	Y2H Array	32296183
Intra	SMCP	P49901	PLSCR3	Homo sapiens	Q9NRY6	Validated Y2H	32296183
Intra	SMCP	P49901	LCE3A	Homo sapiens	Q5TA76	Validated Y2H	32296183
Intra	SMCP	P49901	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	SMCP	P49901	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	SMCP	P49901	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	SMCP	P49901	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	SMCP	P49901	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	SMCP	P49901	PLEKHG4	Homo sapiens	Q58EX7	Validated Y2H	32296183
Intra	SMCP	P49901	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183
Intra	SMCP	P49901	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 21

SPGF21

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Corneal Dystrophy, Subepithelial Mucinous

Subepithelial Mucinous Corneal Dystrophy

SMCD

Infertility

Male Infertility Due To Acephalic Spermatozoa

Acephalic Spermatozoa Syndrome

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13427	SMCP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SMCP	RGD	RGD:3069
Canis familiaris	SMCP	VGNC	VGNC:46552
Mus musculus	SMCP	MGD	MGI:96945
Macaca mulatta	SMCP	VGNC	VGNC:77816
Bos taurus	SMCP	VGNC	VGNC:59191

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