MT1E - metallothionein 1E Gene

Homo sapiens

Also known as MT1; MTD; MT-1E; MT-IE

Gene ID: 4493 | Gene type: protein coding

About MT1E

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,625,781-56,627,112 (from NCBI)

This gene has 3 transcripts (splice variants), 186 orthologues and 11 paralogues. Broad expression in liver (RPKM 106.4), small intestine (RPKM 103.9) and 20 other tissues.

Summary

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MT1E Products(2)

mRNA	Protein	Name
NM_001363555.2	NP_001350484.1	metallothionein-1E isoform 1
NM_175617.4	NP_783316.2	metallothionein-1E isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	16827180	GOA
involved in cellular response to zinc ion	IEP IEP: Inferred from expression pattern	8119276	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8619255	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8619255	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1E Protein Structure

Metallothio

0
61 a.a.

Protein Preferred Names

Protein Names

metallothionein-1E

metallothionein 1E (functional)

MT1E Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MT1E	P04732	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	MT1E	P04732	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	MT1E	P04732	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Frontometaphyseal Dysplasia 1

FMD1

Fmd

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08737	MT1E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MT1E	MGD	MGI:97171

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