MXI1 - MAX interactor 1, dimerization protein Gene

Homo sapiens

Also known as MXI; MAD2; MXD2; bHLHc11

Gene ID: 4601 | Gene type: protein coding

About MXI1

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,207,605-110,287,365 (from NCBI)

This gene has 38 transcripts (splice variants), 258 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 23.6), brain (RPKM 22.2) and 25 other tissues.

Summary

Expression of the c-Myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

MXI1 Products(3)

mRNA	Protein	Name
NM_001008541.1	NP_001008541.1	max-interacting protein 1 isoform c
NM_005962.5	NP_005953.4	max-interacting protein 1 isoform a
NM_130439.3	NP_569157.2	max-interacting protein 1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11875718	GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8425219	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9184233	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11875718	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	8425219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MXI1 Protein Structure

HLH

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

max-interacting protein 1

MAX dimerization protein 2

MXI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MXI1	P50539	MAX	Homo sapiens	P61244-2	Y2H Prey Pooling	25416956
Intra	MXI1	P50539	ENTPD5	Homo sapiens	O75356	Y2H Prey Pooling	25416956
Intra	MXI1	P50539	MAX	Homo sapiens	P61244	Y2H	9184233

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Neurofibrosarcoma

Neurosarcoma

Malignant Peripheral Nerve Sheath Tumor

Prostatic Adenoma

Prostatic Hyperplasia	Adenoma - Prostate
Adenoma Of Prostate	Benign Adenoma Of Prostate
Prostate Adenoma	Benign Prostatic Hyperplasia

Shigellosis

Dysentery, Bacillary	Bacillary Dysentery
Shigella Boydii Infectious Disease	Shigella Flexneri Infectious Disease
Shigella Gastroenteritis	Shigella Sonnei Infectious Disease
Shigella Infections

Small Cell Carcinoma

Small Cell Carcinoma, Intermediate Cell	Intermediate Cell Small Cell Carcinoma
Small Cell Carcinoma - Intermediate Cell	Small Cell Carcinoma Of Lung
Carcinoma, Small Cell

Glanders

Farcy Pipes	Infection Due To Pseudomonas Mallei
Burkholderia Mallei	Burkholderia Mallei Infection
Equina	Equine Glanders
Farcy	Farcy Buds
Farcy Cords	Infection Due To Actinobacillus Mallei
Infection Due To Malleomyces Mallei	Maliasmus
Malleus	Farce
Actinobacillosis	Actinobacillus Infection

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08864	MXI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MXI1	VGNC	VGNC:31773
Canis familiaris	MXI1	VGNC	VGNC:43515
Felis catus	MXI1	VGNC	VGNC:68366
Mus musculus	MXI1	MGD	MGI:97245
Macaca mulatta	MXI1	VGNC	VGNC:75087
Rattus norvegicus	MXI1	RGD	RGD:3128

Name
Email *

	Sorry, but the email address you supplied was invalid.