2. Gene
  3. NBL1 - NBL1, DAN family BMP antagonist Gene

NBL1 - NBL1, DAN family BMP antagonist Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NB; DAN; NO3; DAND1; D1S1733E

Gene ID: 4681 | Gene type: protein coding

About NBL1

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,643,229-19,658,452 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 2 paralogues. Broad expression in ovary (RPKM 113.9), prostate (RPKM 98.5) and 20 other tissues.

Summary

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

NBL1 Products(8)

mRNA Protein Name
NM_001204084.3 NP_001191013.1 neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001204085.2 NP_001191014.1 neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001204086.3 NP_001191015.1 neuroblastoma suppressor of tumorigenicity 1 isoform 3
NM_001278164.2 NP_001265093.1 neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001278165.2 NP_001265094.1 neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001278166.2 NP_001265095.1 neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_005380.8 NP_005371.2 neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_182744.4 NP_877421.2 neuroblastoma suppressor of tumorigenicity 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
23063586 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
23063586 GOA
involved in negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
25561725 GOA
involved in sequestering of BMP from receptor via BMP binding IDA
IDA: Inferred from direct assay
23063586 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
11594460 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NBL1 Protein Structure

DAN

DAN: DAN domain (21 - 124)

  • 0
  • 100
  • 181 a.a.
Protein Preferred Names Protein Names

neuroblastoma suppressor of tumorigenicity 1

DAN domain family member 1

Recombinant NBL1 Proteins

Cat. No. Product Name Accession Purity
HY-P74736 NBL1 Protein, Human (HEK293, His) P41271 (A17-D181) ≥95%
HY-P74737 NBL1 Protein, Human (HEK293, Fc) P41271 (A17-D181) ≥95%

Related Diseases

Diseases Alias
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Nodular Ganglioneuroblastoma

Ganglioneuroblastoma, Nodular
Neuroblastoma 1

Neuroblastoma, Susceptibility To, 1

NBLST1

Neuroblastoma, Susceptibility To, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09056 NBL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NBL1 MGD MGI:104591
Macaca mulatta NBL1 VGNC VGNC:108522
Bos taurus NBL1 VGNC VGNC:108521
Canis familiaris NBL1 VGNC VGNC:84431
Rattus norvegicus NBL1 RGD RGD:3151
Felis catus NBL1 VGNC VGNC:80289
Others NBL1 NCBI