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  4. NBL1 Protein, Human (HEK293, Fc)

NBL1 Protein, Human (HEK293, Fc)

Cat. No.: HY-P74737
Handling Instructions

NBL1 protein, identified as a potential tumor suppressor gene in neuroblastoma, plays a crucial role in inhibiting cells from progressing into the critical G1/S stage of the transformation process. Functioning as a homodimer, NBL1 underscores its involvement in regulatory mechanisms governing cellular transformation and emphasizes its potential contributions to maintaining normal cellular growth control. NBL1 Protein, Human (HEK293, Fc) is the recombinant human-derived NBL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NBL1 Protein, Human (HEK293, Fc) is 165 a.a., with molecular weight of 55-60 kDa.

For research use only. We do not sell to patients.

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Description

NBL1 protein, identified as a potential tumor suppressor gene in neuroblastoma, plays a crucial role in inhibiting cells from progressing into the critical G1/S stage of the transformation process. Functioning as a homodimer, NBL1 underscores its involvement in regulatory mechanisms governing cellular transformation and emphasizes its potential contributions to maintaining normal cellular growth control. NBL1 Protein, Human (HEK293, Fc) is the recombinant human-derived NBL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NBL1 Protein, Human (HEK293, Fc) is 165 a.a., with molecular weight of 55-60 kDa.
Background

NBL1 protein emerges as a potential tumor suppressor gene in neuroblastoma, suggesting its pivotal role in impeding cells from progressing into the critical G1/S stage of the transformation process. Notably, NBL1 functions as a homodimer, highlighting its involvement in regulatory mechanisms that govern cellular transformation and underscoring its potential contributions to the maintenance of normal cellular growth control.
Species

Human
Source

HEK293
Tag

C-hFc
Accession

P41271 (A17-D181)
Gene ID

100532736  [NCBI]/4681  [NCBI]
Molecular Construction
N-term
NBL1 (A17-D181)
Accession # P41271
hFc
C-term
Synonyms
Neuroblastoma suppressor of tumorigenicity 1; Protein N03; NBL1; DAN; DAND1
Molecular Weight

55-60 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

NBL1 Protein, Human (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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