NDUFV3 - NADH:ubiquinone oxidoreductase subunit V3 Gene

Homo sapiens

Also known as CI-10k; CI-9KD

Gene ID: 4731 | Gene type: protein coding

About NDUFV3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,893,309-42,913,299 (from NCBI)

This gene has 4 transcripts (splice variants) and 180 orthologues. Ubiquitous expression in fat (RPKM 8.3), heart (RPKM 7.9) and 25 other tissues.

Summary

The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NDUFV3 Products(2)

mRNA	Protein	Name
NM_001001503.2	NP_001001503.1	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform b precursor
NM_021075.4	NP_066553.3	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24344204	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial ATP synthesis coupled electron transport	IMP IMP: Inferred from mutant phenotype	24746669	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA
part of respiratory chain complex I	IMP IMP: Inferred from mutant phenotype	24746669	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 7

COXPD7	Combined Oxidative Phosphorylation Defect Type 7
Severe C12orf65-Related Combined Oxidative Phosphorylation Defect	Severe C12orf65-Related Coxpd
Combined Oxidative Phosphorylation Deficiency, Type 7

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09167	NDUFV3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NDUFV3	VGNC	VGNC:31976
Rattus norvegicus	NDUFV3	RGD	RGD:621020
Canis familiaris	NDUFV3	VGNC	VGNC:43712
Felis catus	NDUFV3	VGNC	VGNC:102786
Macaca mulatta	NDUFV3	VGNC	VGNC:75300
Mus musculus	NDUFV3	MGD	MGI:1890894

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