NELL2 - neural EGFL like 2 Gene

Homo sapiens

Also known as NRP2

Gene ID: 4753 | Gene type: protein coding

About NELL2

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:44,508,275-44,921,848 (from NCBI)

This gene has 20 transcripts (splice variants), 240 orthologues and 1 paralogue. Biased expression in brain (RPKM 55.4), duodenum (RPKM 9.0) and 5 other tissues.

Summary

The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

NELL2 Products(5)

mRNA	Protein	Name
NM_001145107.2	NP_001138579.1	protein kinase C-binding protein NELL2 isoform a
NM_001145108.2	NP_001138580.1	protein kinase C-binding protein NELL2 isoform b precursor
NM_001145109.2	NP_001138581.1	protein kinase C-binding protein NELL2 isoform c precursor
NM_001145110.2	NP_001138582.1	protein kinase C-binding protein NELL2 isoform d
NM_006159.2	NP_006150.1	protein kinase C-binding protein NELL2 isoform b precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	32198364	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	32198364	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	32198364	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NELL2 Protein Structure

Laminin_G_2

VWC

EGF_CA

cEGF

VWC

0
200
400
600
816 a.a.

Protein Preferred Names

Protein Names

protein kinase C-binding protein NELL2

NEL-like protein 2

Recombinant NELL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75936	NELL2 Protein, Human (sf9, His)	Q99435 (L22-L816)	≥95%

Related Diseases

Diseases

Alias

Childhood Infratentorial Ependymoma

Pediatric Infratentorial Ependymoma

Childhood Ependymoma

Allergic Contact Dermatitis

Dermatitis, Allergic Contact	Contact Dermatitis, Allergic
Dermatitis Allergic Contact	Allergic Contact Eczema
Acd - [Allergic Contact Dermatitis]	Allergic Contact Dermatitis, Unspecified Cause
Allergic Dermatitis	Allergic Eczema
Allergy Dermatitis	Allergy Eczema
Allergic Contact Eczema Due To Clothing Or Footwear	Perfume Allergic Contact Dermatitis
Allergic Contact Dermatitis Due To Cosmetics	Allergic Contact Eczema Due To Cosmetics Or Fragrances
Allergic Contact Eczema Due To Dental Materials	Allergic Contact Eczema Due To Food Flavours Or Additives
Allergic Contact Eczema Due To Hairdressing Products	Allergic Contact Eczema Due To Metals Or Metal Salts
Allergic Contact Eczema Due To Proteins	Allergic Contact Eczema Due To Plastics Or Resin Systems
Allergic Contact Eczema Due To Preservatives Or Biocides	Allergic Contact Eczema Due To Rubber Chemicals
Rubber Dermatitis	Allergic Contact Eczema Due To Systemic Medicaments
Allergic Contact Eczema Due To Topical Medicaments	Allergic Contact Dermatitis Due To Drugs In Contact With Skin

Posterior Fossa Ependymoma

Spinal Cord Ependymoma

Ependymal Neoplasm Of The Spinal Cord	Spinal Ependymoma
Ependymoma Of Spinal Cord

Rela Fusion-Positive Ependymoma

Supratentorial C11orf95-Rela Fused Ependymoma

C11orf95 Fusion-Positive Supratentorial Ependymoma

High Grade Ependymoma

Ependymal Neoplasm	Ependymal Tumors
Malignant Ependymoma	Ependymal Tumor
Anaplastic Ependymoma	Experimental Organism Malignant Ependymoma
Ependymoma Of Brain

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms	Cerebral Ventricle Neoplasm
Intraventricular Tumor Of Brain

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09205	NELL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NELL2	MGD	MGI:1858510
Rattus norvegicus	NELL2	RGD	RGD:620999
Macaca mulatta	NELL2	VGNC	VGNC:75313
Canis familiaris	NELL2	VGNC	VGNC:43740
Bos taurus	NELL2	VGNC	VGNC:32003
Felis catus	NELL2	VGNC	VGNC:68461
Others	NELL2	NCBI

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