NFKBIL1 - NFKB inhibitor like 1 Gene

Homo sapiens

Also known as IKBL; NFKBIL

Gene ID: 4795 | Gene type: protein coding

About NFKBIL1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,546,851-31,558,829 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 181 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 7.9), fat (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

NFKBIL1 Products(4)

mRNA	Protein	Name
NM_001144961.2	NP_001138433.1	NF-kappa-B inhibitor-like protein 1 isoform 2
NM_001144962.2	NP_001138434.1	NF-kappa-B inhibitor-like protein 1 isoform 3
NM_001144963.2	NP_001138435.1	NF-kappa-B inhibitor-like protein 1 isoform 4
NM_005007.4	NP_004998.3	NF-kappa-B inhibitor-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20829348	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	20829348	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	20829348	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20829348	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIL1 Protein Structure

Ank_2

0
100
200
300
366 a.a.

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor-like protein 1

I-kappa-B-like protein

NFKBIL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFKBIL1	Q9UBC1	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09264	NFKBIL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NFKBIL1	VGNC	VGNC:68487
Canis familiaris	NFKBIL1	VGNC	VGNC:43784
Bos taurus	NFKBIL1	VGNC	VGNC:32049
Mus musculus	NFKBIL1	MGD	MGI:1340031
Rattus norvegicus	NFKBIL1	RGD	RGD:1303310
Macaca mulatta	NFKBIL1	VGNC	VGNC:104414

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