NHLH2 - nescient helix-loop-helix 2 Gene

Homo sapiens

Also known as HEN2; HH27; NSCL2; bHLHa34

Gene ID: 4808 | Gene type: protein coding

About NHLH2

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:115,831,344-115,841,126 (from NCBI)

This gene has 3 transcripts (splice variants), 104 orthologues, 4 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Predicted to act upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

NHLH2 Products(2)

mRNA	Protein	Name
NM_001111061.2	NP_001104531.1	helix-loop-helix protein 2
NM_005599.3	NP_005590.1	helix-loop-helix protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16314316	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22169038	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NHLH2 Protein Structure

HLH

0
100
135 a.a.

Protein Preferred Names

Protein Names

helix-loop-helix protein 2

HEN-2

NHLH2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NHLH2	Q02577	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	NHLH2	Q02577	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	NHLH2	Q02577	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	NHLH2	Q02577	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	NHLH2	Q02577	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	NHLH2	Q02577	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	NHLH2	Q02577	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	NHLH2	Q02577	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	22169038
Intra	NHLH2	Q02577	KCNIP1	Homo sapiens	Q9NZI2-2	Y2H Prey Pooling	32296183
Intra	NHLH2	Q02577	KCNIP1	Homo sapiens	Q9NZI2-2	Validated Y2H	32296183
Intra	NHLH2	Q02577	KCNIP1	Homo sapiens	Q9NZI2-2	Y2H Array	32296183
Intra	NHLH2	Q02577	TAF1D	Homo sapiens	Q9H5J8	Y2H Array	32296183
Intra	NHLH2	Q02577	TAF1D	Homo sapiens	Q9H5J8	Y2H Prey Pooling	32296183
Intra	NHLH2	Q02577	TAF1D	Homo sapiens	Q9H5J8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 27 Without Anosmia

HH27

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09285	NHLH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NHLH2	RGD	RGD:1308294
Felis catus	NHLH2	VGNC	VGNC:107590
Bos taurus	NHLH2	VGNC	VGNC:32066
Mus musculus	NHLH2	MGD	MGI:97324
Canis familiaris	NHLH2	VGNC	VGNC:43799
Macaca mulatta	NHLH2	VGNC	VGNC:106417

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