NMT1 - N-myristoyltransferase 1 Gene

Homo sapiens

Also known as NMT; HsNMT1

Gene ID: 4836 | Gene type: protein coding

About NMT1

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,061,317-45,109,016 (from NCBI)

This gene has 19 transcripts (splice variants), 281 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 21.5), thyroid (RPKM 17.0) and 25 other tissues.

Summary

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and Viral Proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

NMT1 Products(1)

mRNA	Protein	Name
NM_021079.5	NP_066565.1	glycylpeptide N-tetradecanoyltransferase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glycylpeptide N-tetradecanoyltransferase activity	IDA IDA: Inferred from direct assay	25255805	GOA
enables myristoyltransferase activity	IDA IDA: Inferred from direct assay	22865860	GOA
enables peptidyl-lysine N6-myristoyltransferase activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26621918	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in N-terminal peptidyl-glycine N-myristoylation	IDA IDA: Inferred from direct assay	25255805	GOA
involved in cellular ketone metabolic process	IDA IDA: Inferred from direct assay	22865860	GOA
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	34999170	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9353336	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9506952	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMT1 Protein Structure

NMT

NMT_C

0
100
200
300
400
496 a.a.

Protein Preferred Names

Protein Names

glycylpeptide N-tetradecanoyltransferase 1

alternative, short form NMT-S

NMT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NMT1	P30419	ACBD6	Homo sapiens	Q9BR61	Validated Y2H	32296183
Intra	NMT1	P30419	ACBD6	Homo sapiens	Q9BR61	Gal4 VP16 Complement	26621918
Intra	NMT1	P30419	ACBD6	Homo sapiens	Q9BR61	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gallbladder Cancer

Gallbladder Carcinoma	Gallbladder Neoplasm
Malignant Neoplasm Of Gallbladder	Malignant Tumour Of Gallbladder
Gallbladder Ca	Localized Malignant Gallbladder Neoplasm
Malignant Tumor Of The Gallbladder	Tumor Of The Gallbladder
Cancer Of The Gallbladder	Carcinoma Gallbladder
Carcinoma Of Gallbladder	Gallbladder Neoplasms
Malignant Neoplasm Of Gallbladder Localized	Cancer Of Gallbladder
Primary Malignant Neoplasm Of Gallbladder

Partial Fetal Alcohol Syndrome

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Atrial Heart Septal Defect

Atrial Septal Defect	Atrial Septal Defects
Atrioseptal Defect	Auricular Septal Defect
Congenital Atrial Septal Defect	Interatrial Septal Defect
Interauricular Septal Defect	Heart Septal Defects, Atrial
Septal Defect, Atrial

Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency	Mitochondrial Complex Iv Deficiency
Cox Deficiency	Cytochrome-C Oxidase Deficiency Disease
MC1DN4	Cytochrome-C Oxidase Deficiency
MC4DN1	Mitochondrial Complex I Deficiency, Nuclear Type 4
Complex 4 Mitochondrial Respiratory Chain Deficiency	Complex Iv Deficiency
Mitochondrial Complex 1 Deficiency, Nuclear Type 4	Nuclear Type Mitochondrial Complex I Deficiency 4
Deficiency Of Mitochondrial Respiratory Chain Complex4	MT-C4D
Complex Iv Mitochondrial Respiratory Chain Deficiency	Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency
Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112258	IMP-1088	Inhibitor	99.16%	Unkown
HY-147308	Zelenirstat	Inhibitor	99.05%	Unkown
HY-RS09389	NMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NMT1	VGNC	VGNC:68507
Canis familiaris	NMT1	VGNC	VGNC:43866
Rattus norvegicus	NMT1	RGD	RGD:628642
Macaca mulatta	NMT1	VGNC	VGNC:75360
Bos taurus	NMT1	VGNC	VGNC:32137
Mus musculus	NMT1	MGD	MGI:102579
Others	NMT1	NCBI

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