SLC11A2 - solute carrier family 11 member 2 Gene

Homo sapiens

Also known as DCT1; DMT1; AHMIO1; NRAMP2

Gene ID: 4891 | Gene type: protein coding

About SLC11A2

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,952,263-51,028,886 (from NCBI)

This gene has 33 transcripts (splice variants), 276 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in duodenum (RPKM 12.8), thyroid (RPKM 12.7) and 25 other tissues.

Summary

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

SLC11A2 Products(18)

mRNA	Protein	Name
NM_000617.3	NP_000608.1	natural resistance-associated macrophage protein 2 isoform 3
NM_001174125.2	NP_001167596.1	natural resistance-associated macrophage protein 2 isoform 1
NM_001174126.2	NP_001167597.1	natural resistance-associated macrophage protein 2 isoform 2
NM_001174127.2	NP_001167598.1	natural resistance-associated macrophage protein 2 isoform 2
NM_001174128.2	NP_001167599.1	natural resistance-associated macrophage protein 2 isoform 3
NM_001174129.2	NP_001167600.1	natural resistance-associated macrophage protein 2 isoform 3
NM_001174130.2	NP_001167601.1	natural resistance-associated macrophage protein 2 isoform 4
NM_001379446.1	NP_001366375.1	natural resistance-associated macrophage protein 2 isoform 5
NM_001379447.2	NP_001366376.1	natural resistance-associated macrophage protein 2 isoform 2
NM_001379448.1	NP_001366377.1	natural resistance-associated macrophage protein 2 isoform 6
NM_001379455.1	NP_001366384.1	natural resistance-associated macrophage protein 2 isoform 1
NM_001414744.1	NP_001401673.1	natural resistance-associated macrophage protein 2 isoform 3
NM_001414745.1	NP_001401674.1	natural resistance-associated macrophage protein 2 isoform 3
NM_001414746.1	NP_001401675.1	natural resistance-associated macrophage protein 2 isoform 3
NM_001414747.1	NP_001401676.1	natural resistance-associated macrophage protein 2 isoform 7
NM_001414748.1	NP_001401677.1	natural resistance-associated macrophage protein 2 isoform 8
NM_001414749.1	NP_001401678.1	natural resistance-associated macrophage protein 2 isoform 9
NM_001414750.1	NP_001401679.1	natural resistance-associated macrophage protein 2 isoform 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadmium ion binding	IDA IDA: Inferred from direct assay	25326704	GOA
enables cadmium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	12662899	GOA
NOT enables calcium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
NOT enables chromium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
enables cobalt ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
enables copper ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	12734107	GOA
enables ferrous iron transmembrane transporter activity	IDA IDA: Inferred from direct assay	12734107	GOA
enables ferrous iron transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	25491917	GOA
enables inorganic cation transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	12475959	GOA
enables lead ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	12127992	GOA
enables manganese ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
enables nickel cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15880641	GOA
enables retromer complex binding	IDA IDA: Inferred from direct assay	20164305	GOA
enables solute:proton symporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
enables transition metal ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	25326704	GOA
enables vanadium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
NOT enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	17109629	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18082289	GOA
involved in cadmium ion transmembrane transport	IDA IDA: Inferred from direct assay	12662899	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	18082289	GOA
involved in cobalt ion transport	IDA IDA: Inferred from direct assay	17109629	GOA
involved in copper ion transport	IDA IDA: Inferred from direct assay	12734107	GOA
NOT involved in detection of oxygen	IEP IEP: Inferred from expression pattern	18419598	GOA
involved in detection of oxygen	IEP IEP: Inferred from expression pattern	18419598	GOA
involved in iron import into cell	IDA IDA: Inferred from direct assay	17109629	GOA
involved in iron ion transmembrane transport	IDA IDA: Inferred from direct assay	17293870	GOA
involved in iron ion transport	IDA IDA: Inferred from direct assay	12734107	GOA
involved in lead ion transport	IDA IDA: Inferred from direct assay	12127992	GOA
involved in manganese ion transport	IDA IDA: Inferred from direct assay	17109629	GOA
involved in multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	15459009	GOA
involved in nickel cation transport	IDA IDA: Inferred from direct assay	17109629	GOA
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18419598	GOA
NOT involved in response to iron ion	IEP IEP: Inferred from expression pattern	15792797	GOA
involved in response to iron ion	IEP IEP: Inferred from expression pattern	12209011	GOA
involved in vanadium ion transport	IDA IDA: Inferred from direct assay	17109629	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	15880641	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12475959	GOA
located in basal part of cell	IDA IDA: Inferred from direct assay	15880641	GOA
located in cell surface	IDA IDA: Inferred from direct assay	12475959	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11891802	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15880641	GOA
located in early endosome	IDA IDA: Inferred from direct assay	12475959	GOA
located in extracellular vesicle	IDA IDA: Inferred from direct assay	27462458	GOA
located in late endosome	IDA IDA: Inferred from direct assay	12475959	GOA
located in late endosome membrane	IDA IDA: Inferred from direct assay	10751401	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	10751401	GOA
located in lysosome	IDA IDA: Inferred from direct assay	12475959	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15880641	GOA
part of paraferritin complex	IDA IDA: Inferred from direct assay	11842004	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10751401	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15792797	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	11891802	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	15880641	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	18776082	GOA
located in vacuole	IMP IMP: Inferred from mutant phenotype	17932044	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC11A2 Protein Structure

Nramp

0
100
200
300
400
500
568 a.a.

Protein Preferred Names

Protein Names

natural resistance-associated macrophage protein 2

DMT-1

SLC11A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC11A2	P49281	NDFIP1	Homo sapiens	Q9BT67	Anti Bait CoIP	19706893
Intra	SLC11A2	P49281	NEDD4L	Homo sapiens	Q96PU5	Anti Bait CoIP	19706893

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anemia, Hypochromic Microcytic, With Iron Overload 1

Microcytic Anemia With Liver Iron Overload	AHMIO1
Hypochromic Microcytic Anemia With Iron Overload	Microcytic Anemia And Hepatic Iron Overload
Hypochromic Microcytic Anemia	Anemia, Hypochromic Microcytic With Iron Overload
Microcytic Hypochromic Anemia

Hypochromic Microcytic Anemia

Anemia, Hypochromic Microcytic

Microcytic Hypochromic Anemia

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Iron Deficiency Anemia

Iron-Deficiency Anemia	Fe Deficiency Anaemia
Ida - [Iron Deficiency Anemia]	Fe - [Iron] Deficiency Anemia Nos

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Iron Metabolism Disease

Iron Deficiency	Iron Disorder
Iron Metabolism Disorders	Disorder Of Iron Metabolism
Iron	Fe Deficiency
Iron Storage Disease	Iron Storage Disorder

Hemosiderosis

Haemosiderosis

Iron Overload

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Hemochromatosis, Type 4

Hemochromatosis Type 4	Hemochromatosis Due To Defect In Ferroportin
HFE4	Hemochromatosis, Autosomal Dominant
Autosomal Dominant Hereditary Hemochromatosis	Ferroportin Disease
Hemochromatosis 4	Hemochromatosis Autosomal Dominant

Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder

Atransferrinemia

Familial Hypotransferrinemia	Congenital Atransferrinemia
Hypotransferrinemia, Familial	Congenital Hypotransferrinemia
ATRAF

Anemia, Sideroblastic, 1

Xlsa	X-Linked Sideroblastic Anemia
Hypochromic Anemia	Anh1
Hereditary Iron-Loading Anemia	Anemia, Sideroblastic, X-Linked
Anemia, Hereditary Sideroblastic	Erythroid 5-Aminolevulinate Synthase Deficiency
Hereditary Sideroblastic Anemia	SIDBA1
Anemia, Hypochromic	Sideroblastic Anemia 1
Anemia Hypochromic	X Chromosome-Linked Sideroblastic Anemia
Sideroblastic Anaemia 1	X-Linked Sideroblastic Anaemia
Anemia Hereditary Sideroblastic	Anemia Sex-Linked Hypochromic Sideroblastic
Congenital Sideroblastic Anemia	Sideroblastic Anemia X-Linked
Anemia, Sex-Linked Hypochromic Sideroblastic	Congenital Sideroblastic Anaemia
X-Linked Pyridoxine-Responsive Sideroblastic Anemia	Anemia Congenital Sideroblastic
Anemia, Sideroblastic, Type 1	Sex-Linked Hypochromic Sideroblastic Anaemia
Autosomal Recessive Sideroblastic Anaemia	Familial Sex Linked Hypochromic Anaemia

Iron Overload In Africa

African Iron Overload	Bantu Siderosis
African Hemochromatosis	Hereditary Iron Overload And African Americans
African Nutritional Hemochromatosis	African Siderosis

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Hemochromatosis, Type 3

Hemochromatosis Type 3	HFE3
Hemochromatosis Due To Defect In Transferrin Receptor 2	Tfr2-Related Hemochromatosis
Tfr2-Related Hereditary Hemochromatosis	Hemochromatosis 3

Neurodegeneration With Brain Iron Accumulation 3

Neuroferritinopathy	NBIA3
Ferritin-Related Neurodegeneration	Hereditary Ferritinopathy
Basal Ganglia Disease, Adult-Onset	Adult Basal Ganglia Disease
Neuroferritinopathy	Basal Ganglia Disease, Adult-Onset
Basal Ganglia Disease Adult-Onset	Adult-Onset Basal Ganglia Disease
Neurodegeneration, With Brain Iron Accumulation, Type 3

Hyperferritinemia With Or Without Cataract

Hyperferritinemia-Cataract Syndrome	Hhcs
Hereditary Hyperferritinemia With Congenital Cataracts	Hyperferritinemia, Hereditary, With Congenital Cataracts
Bonneau-Beaumont Syndrome	HRFTC
Hereditary Hyperferritinemia-Cataract Syndrome	Cataract-Hyperferritinemia Syndrome
Hyperferritinemia Cataract Syndrome	Hereditary Hyperferritinemia Cataract Syndrome

Neurodegeneration With Brain Iron Accumulation 1

Pantothenate Kinase-Associated Neurodegeneration	Pkan
NBIA1	Hallervorden-Spatz Disease
Hallervorden-Spatz Syndrome	Pigmentary Pallidal Degeneration
Neuroaxonal Dystrophy, Late Infantile	Neurodegeneration With Brain Iron Accumulation Type 1
Classic Pantothenate Kinase-Associated Neurodegeneration	Pkan Neuroaxonal Dystrophy, Juvenile-Onset
Brain Iron Accumulation Type I Syndrome	Nbia
Neurodegeneration With Brain Iron Accumulation	Nbia1, Classic Form
Neurodegeneration With Brain Iron Accumulation Type 1, Classic Form	Pkan, Classic Form
Atypical Pantothenate Kinase-Associated Neurodegeneration	Nbia1, Atypical Form
Neurodegeneration With Brain Iron Accumulation Type 1, Atypical Form	Pkan, Atypical Form
Hss	Pkan Neuroaxonal Dystrophy Juvenile-Onset
Neurodegeneration, With Brain Iron Accumulation, Type 1

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Nutritional Deficiency Disease

Malnutrition	Nutritional Disorder
Nutritional Deficiency	Nutrition
Deficiency Diseases	Carbamoyl-Phosphate Synthase I Deficiency Disease
Nutrition Disorders

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Beta-Thalassemia Major

Cooley'S Anemia	Cooley Anemia
Mediterranean Anemia

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Retinal Degeneration

Degeneration Of Retina

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12995	SLC11A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC11A2	MGD	MGI:1345279
Macaca mulatta	SLC11A2	VGNC	VGNC:77383
Rattus norvegicus	SLC11A2	RGD	RGD:3684
Canis familiaris	SLC11A2	VGNC	VGNC:46217
Felis catus	SLC11A2	VGNC	VGNC:65187
Others	SLC11A2	NCBI

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