ACR - acrosin Gene

Homo sapiens

Gene ID: 49 | Gene type: protein coding

About ACR

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,738,204-50,745,339 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele and 105 orthologues. Restricted expression toward testis (RPKM 44.8).

Summary

Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active Enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]

ACR Products(1)

mRNA	Protein	Name
NM_001097.3	NP_001088.2	acrosin precursor

ACR Protein Structure

Trypsin

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

acrosin

acrosin light and heavy chain prepropeptide

Related Diseases

Diseases

Alias

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Spermatogenic Failure 6

Globozoospermia	SPGF6
Round-Headed Spermatozoa	Acrosome Malformation Of Spermatozoa
Spermatogenic Failure 9	Spermatozoa, Round-Headed
Globozoospermia, Complete	Globozoospermia, Total
Mae Infertility Due To Round-Headed Spermatozoa	Male Infertility Due To Globozoospermia
Male Infertility Due To Round-Headed Spermatozoa	Round-Headed Sperm Syndrome
Spgf9	Teratozoospermia

Chronic Congestive Splenomegaly

Pulmonary Coin Lesion

Coin Lesion Of Lung	Solitary Pulmonary Nodule
Coin Lesion Lung

Rectum Lymphoma

Lymphoma Of Rectum

Supine Hypotensive Syndrome

Maternal Hypotension Syndrome	Antepartum Maternal Hypotension Syndrome
Postpartum Maternal Hypotension Syndrome	Maternal Hypotension Syndrome, Antepartum Condition Or Complication
Maternal Hypotension Syndrome, Postpartum Condition Or Complication	Maternal Hypotension Syndrome, Unspecified Trimester

Nutmeg Liver

Chronic Passive Congestion Of Liver

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Waterhouse-Friderichsen Syndrome

Fatal Pneumococcal Waterhouse-Friderichsen Syndrome	Meningococcal Hemorrhagic Adrenalitis
Waterhouse-Friderichsen Syndrome, Meningococcal	Meningococcal Haemorrhagic Adrenalitis
Meningococcal Adrenal Syndrome	Acute Adrenal Insufficiency With Meningococcal Septicaemia
Adrenal Haemorrhage Syndrome	Waterhouse-Friderichsen Disease
Meningococcal Waterhouse-Friderichsen Syndrome	Haemorrhagic Meningococcal Adrenitis

Mucocele Of Salivary Gland

Ranula	Salivary Cyst
Salivary Gland Mucocele	Mucous Retention Cyst Of Salivary Gland
Retention Cyst Of Salivary Gland	Sialocele
Cyst Of Salivary Gland Or Duct	Extravasation Cyst Of Salivary Gland

Colonic Lymphangioma

Lymphangioma Of Colon

Colon Lymphangioma

Sialolithiasis

Sialolith	Stone Of Salivary Gland Or Duct
Salivary Gland Calculi	Salivary Gland Stone
Calculus Of Salivary Gland Or Duct	Calculus Of Salivary Gland
Salivary Calculus	Salivary Gland Calculus
Salivary Stone	Salivary Duct Calculi
Sialodocholithiasis

Parasitic Ichthyosporea Infectious Disease

Rhinosporidiosis

Infection By Rhinosporidium Seeberi

Rhinosporosis

Spermatogenic Failure 9

Male Infertility Due To Globozoospermia	SPGF9
Male Infertility Due To Round-Headed Spermatozoa	Globozoospermia, Complete
Globozoospermia, Total	Globozoospermia
Globozoospermia Syndrome	Round-Headed Sperm Syndrome
Globozoospermia Complete	Globozoospermia Total

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Acquired Hemangioma

Mucinous Adenofibroma

Schizophrenia 14

Sczd14	Schizophrenia, Susceptibility To, 14
Schizophrenia Susceptibility Locus, Chromosome 2q32-Related

Urinary Bladder Small Cell Neuroendocrine Carcinoma

Small Cell Neuroendocrine Carcinoma Of The Urinary Bladder

Small Cell/Neuroendocrine Carcinoma Of Urinary Bladder

Lemierre'S Syndrome

Lemierre Syndrome	Lemierre Postanginal Sepsis
Necrobacillosis	Postanginal Sepsis Secondary To Orophyngeal Infection
Septic Phlebitis Of The Internal Jugular Vein	Fusobacterium Infections
Acute Sore Throat	Human Necrobacillosis
Postanginal Sepsis	Oropharyngeal Infection Leading To Secondary Septic Thrombophlebitis Of The Internal Jugular Vein

Chronic Dacryocystitis

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10684	Pridopidine	Antagonist	99.85%	Phase 3
HY-19845	Ordopidine	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129126	NC9	Inhibitor	/	Unkown
HY-RS00193	ACR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-19845A	Ordopidine hydrochloride	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ACR	VGNC	VGNC:69386
Felis catus	ACR	VGNC	VGNC:59529
Rattus norvegicus	ACR	RGD	RGD:2024
Bos taurus	ACR	VGNC	VGNC:25557
Mus musculus	ACR	MGD	MGI:87884
Canis familiaris	ACR	VGNC	VGNC:37526
Macaca fascicularis	ACR	NCBI	NCBI:102115325
Others	ACR	NCBI

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