OAS1 - 2'-5'-oligoadenylate synthetase 1 Gene

Homo sapiens

Also known as OIAS; IFI-4; OIASI; IMD100; E18/E16

Gene ID: 4938 | Gene type: protein coding

About OAS1

Cytogenetic location: 12q24.13 Genomic coordinates (GRCh38): 12:112,906,962-112,933,219 (from NCBI)

This gene has 33 transcripts (splice variants), 167 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 18.0), colon (RPKM 15.8) and 24 other tissues.

Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular Antiviral response, and has been implicated in Other cellular processes like cell growth and Apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral Infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]

OAS1 Products(15)

mRNA	Protein	Name
NM_001032409.3	NP_001027581.1	2'-5'-oligoadenylate synthase 1 isoform 3
NM_001320151.2	NP_001307080.1	2'-5'-oligoadenylate synthase 1 isoform 4
NM_001406020.1	NP_001392949.1	2'-5'-oligoadenylate synthase 1 isoform 5
NM_001406021.1	NP_001392950.1	2'-5'-oligoadenylate synthase 1 isoform 6
NM_001406022.1	NP_001392951.1	2'-5'-oligoadenylate synthase 1 isoform 7
NM_001406023.1	NP_001392952.1	2'-5'-oligoadenylate synthase 1 isoform 8
NM_001406024.1	NP_001392953.1	2'-5'-oligoadenylate synthase 1 isoform 9
NM_001406025.1	NP_001392954.1	2'-5'-oligoadenylate synthase 1 isoform 10
NM_001406026.1	NP_001392955.1	2'-5'-oligoadenylate synthase 1 isoform 11
NM_001406027.1	NP_001392956.1	2'-5'-oligoadenylate synthase 1 isoform 12
NM_001406029.1	NP_001392958.1	2'-5'-oligoadenylate synthase 1 isoform 13
NM_001406030.1	NP_001392959.1	2'-5'-oligoadenylate synthase 1 isoform 14
NM_001412228.1	NP_001399157.1	2'-5'-oligoadenylate synthase 1 isoform 15
NM_002534.4	NP_002525.2	2'-5'-oligoadenylate synthase 1 isoform 2
NM_016816.4	NP_058132.2	2'-5'-oligoadenylate synthase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2'-5'-oligoadenylate synthetase activity	IDA IDA: Inferred from direct assay	2434505	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	12799444	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15039538	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	34581622	GOA
involved in antiviral innate immune response	IEP IEP: Inferred from expression pattern	25930096	GOA
involved in cellular response to interferon-alpha	IDA IDA: Inferred from direct assay	3753689	GOA
involved in cellular response to interferon-beta	IDA IDA: Inferred from direct assay	2434505	GOA
involved in cellular response to virus	IEP IEP: Inferred from expression pattern	28146100	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	19923450	GOA
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23575436	GOA
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	23575436	GOA
involved in interleukin-27-mediated signaling pathway	IEP IEP: Inferred from expression pattern	32270034	GOA
involved in negative regulation of IP-10 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of chemokine (C-X-C motif) ligand 2 production	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	18931074	GOA
involved in positive regulation of cellular respiration	IDA IDA: Inferred from direct assay	31817188	GOA
involved in positive regulation of interferon-beta production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	30822544	GOA
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	11682059	GOA
involved in regulation of ribonuclease activity	IDA IDA: Inferred from direct assay	19923450	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	18931074	GOA
involved in surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	29455859	GOA
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in toll-like receptor 4 signaling pathway	IMP IMP: Inferred from mutant phenotype	30078389	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28640813	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	21245038	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	3753689	GOA
located in cytosol	IDA IDA: Inferred from direct assay	31817188	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25205466	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	2434505	GOA
located in nucleus	IDA IDA: Inferred from direct assay	3753689	GOA
located in ribosome	IDA IDA: Inferred from direct assay	2434505	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OAS1 Protein Structure

NTP_transf_2

OAS1_C

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

2'-5'-oligoadenylate synthase 1

(2-5')oligo(A) synthase 1

OAS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OAS1	P00973	ACTN1	Homo sapiens	P12814	Validated Y2H	25416956
Intra	OAS1	P00973	TRIM27	Homo sapiens	P14373	Y2H Array	31515488
Intra	OAS1	P00973	EXOC5	Homo sapiens	O00471	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Immunodeficiency 100 With Pulmonary Alveolar Proteinosis And Hypogammaglobulinemia

Pulmonary Alveolar Proteinosis With Hypogammaglobulinemia	IMD100
Paphg

Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia

Oas1 Deficiency

Oas1-Related Infantile-Onset Pulmonary Alveolar Proteinosis-Hypogammaglobulinemia

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

West Nile Fever

Yellow Fever

Urban Yellow Fever	Jungle Yellow Fever
Sylvatic Yellow Fever	Yf
Yellow Fever, Sylvan	Bronze John
Yellow Jack	Yf- [Yellow Fever]
Febris Flava

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Pulmonary Alveolar Proteinosis

Viral Infectious Disease

Viral Disease	Arbovirus Infections
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Rubella

German Measles	Three Day Measles
Rubella Nos

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Mouth Disease

Mouth Diseases

Mouth Disorders

Diabetes Mellitus

Diabetes

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09727	OAS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	OAS1	VGNC	VGNC:68606
Macaca mulatta	OAS1	VGNC	VGNC:75570
Rattus norvegicus	OAS1	RGD	RGD:621760
Canis familiaris	OAS1	VGNC	VGNC:44086

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