ODF2 - outer dense fiber of sperm tails 2 Gene

Homo sapiens

Also known as CT134; ODF84; ODF2/1; ODF2/2

Gene ID: 4957 | Gene type: protein coding

About ODF2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,455,185-128,501,292 (from NCBI)

This gene has 22 transcripts (splice variants), 248 orthologues and 1 paralogue. Biased expression in testis (RPKM 95.4), lymph node (RPKM 8.1) and 9 other tissues.

Summary

The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]

ODF2 Products(23)

mRNA	Protein	Name
NM_001242352.2	NP_001229281.1	outer dense fiber protein 2 isoform 11
NM_001242353.2	NP_001229282.1	outer dense fiber protein 2 isoform 2
NM_001242354.2	NP_001229283.1	outer dense fiber protein 2 isoform 8
NM_001351577.1	NP_001338506.1	outer dense fiber protein 2 isoform 12
NM_001351578.2	NP_001338507.1	outer dense fiber protein 2 isoform 13
NM_001351579.2	NP_001338508.1	outer dense fiber protein 2 isoform 14
NM_001351580.2	NP_001338509.1	outer dense fiber protein 2 isoform 14
NM_001351581.1	NP_001338510.1	outer dense fiber protein 2 isoform 15
NM_001351582.2	NP_001338511.1	outer dense fiber protein 2 isoform 16
NM_001351583.2	NP_001338512.1	outer dense fiber protein 2 isoform 17
NM_001351584.2	NP_001338513.1	outer dense fiber protein 2 isoform 11
NM_001351585.2	NP_001338514.1	outer dense fiber protein 2 isoform 11
NM_001351586.2	NP_001338515.1	outer dense fiber protein 2 isoform 9
NM_001351587.2	NP_001338516.1	outer dense fiber protein 2 isoform 18
NM_001351588.2	NP_001338517.1	outer dense fiber protein 2 isoform 19
NM_002540.5	NP_002531.3	outer dense fiber protein 2 isoform 9
NM_153432.1	NP_702910.1	outer dense fiber protein 2 isoform 3
NM_153433.2	NP_702911.1	outer dense fiber protein 2 isoform 2
NM_153435.1	NP_702913.1	outer dense fiber protein 2 isoform 1
NM_153436.2	NP_702914.1	outer dense fiber protein 2 isoform 4
NM_153437.3	NP_702915.1	outer dense fiber protein 2 isoform 6
NM_153439.1	NP_702917.1	outer dense fiber protein 2 isoform 5
NM_153440.2	NP_702918.1	outer dense fiber protein 2 isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16980960	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	17646400	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centriole-centriole cohesion	IGI IGI: Inferred from genetic interaction	23213374	GOA
involved in cilium organization	IGI IGI: Inferred from genetic interaction	23400999	GOA
involved in protein localization	IMP IMP: Inferred from mutant phenotype	23213374	GOA
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	17646400	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of centriolar subdistal appendage	IDA IDA: Inferred from direct assay	23213374	GOA
located in centriole	IDA IDA: Inferred from direct assay	17646400	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	17646400	GOA
NOT located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

outer dense fiber protein 2

cancer/testis antigen 134

ODF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ODF2	Q5BJF6	NUFIP2	Homo sapiens	Q7Z417	Anti Bait CoIP	35709258

Cross: Cross-species interaction Intra: Intraspecies interaction

ODF2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82060	Cenexin1 Antibody (YA1805)	WB, FC	Human

Related Diseases

Diseases

Alias

Spermatogenic Failure 8

SPGF8

Latex Allergy

Infertility

Seckel Syndrome 7

SCKL7	Microcephalic Primordial Dwarfism, Dauber Type
Seckel Syndrome, Type 7

Orofaciodigital Syndrome Ix

OFD9	Orofaciodigital Syndrome With Retinal Abnormalities
Oral-Facial-Digital Syndrome With Retinal Abnormalities	Orofaciodigital Syndrome 9
Oral-Facial-Digital Syndrome Type 9	Ofds Ix
Oral-Facial-Digital Syndrome, Type Ix	Ofd Syndrome 9
Ofds 9	Oral Facial Digital Syndrome 9
Oral Facial Digital Syndrome Type 9	Orofaciodigital Syndrome Type 9
Orofaciodigital Syndrome, Type Ix

Chromosome 13q14 Deletion Syndrome

Chromosome 13q Deletion Syndrome	Deletion 13q14
Chromosome 13q Deletion	13q Deletion
13q Monosomy	Deletion 13q
Monosomy 13q	Monosomy 13q14
Del(13)(Q14)

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09752	ODF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ODF2	VGNC	VGNC:68619
Bos taurus	ODF2	VGNC	VGNC:32401
Macaca mulatta	ODF2	VGNC	VGNC:75580
Mus musculus	ODF2	MGD	MGI:1098824
Canis familiaris	ODF2	VGNC	VGNC:44099
Rattus norvegicus	ODF2	RGD	RGD:3229

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