Cd2 - Cd2 molecule Gene

Rattus norvegicus

Also known as CD2R; LFA2; OX34; LFA-2; OX-34

Gene ID: 497761 | Gene type: protein coding

About Cd2

Summary

Enables identical protein binding activity; protein self-association; and receptor tyrosine kinase binding activity. Involved in T cell activation and cell-cell adhesion. Located in cell surface and membrane raft. Part of protein-containing complex. Orthologous to human CD2 (CD2 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd2 Products(1)

mRNA	Protein	Name
NM_012830.2	NP_036962.2	T-cell surface antigen CD2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10526406	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9576909	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	1280324	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	18178839	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	8938183	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	8938183	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	9576909	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

T-cell surface antigen CD2

CD2 antigen	LFA-3 receptor
OX-34 antigen	OX-45 surface antigen homolog to human T lymphocyte CD2 antigen
T-cell surface antigen T11/Leu-5

Recombinant Cd2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74322	CD2 Protein, Rat (HEK293, Fc)	Q5I0M6 (R23-P202)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99904	Siplizumab	Inhibitor	96.00%	Phase 2
HY-P99757	Nivatrotamab	Inhibitor	99.40%	Phase 2

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd2	NCBI	NCBI:914
Canis familiaris	Cd2	NCBI	NCBI:607448
Macaca fascicularis	Cd2	NCBI	NCBI:102120798
Canis lupus familiaris	Cd2	NCBI
Mus musculus	Cd2	NCBI	NCBI:12481
Leporidae	Cd2	NCBI
Macaca mulatta	Cd2	NCBI	NCBI:677855

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