2. Gene
  3. Cd2 - CD2 antigen Gene

Cd2 - CD2 antigen Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ly37; LFA-2; Ly-37

Gene ID: 12481 | Gene type: protein coding

About Cd2

Summary

Enables identical protein binding activity. Predicted to be involved in T cell activation; heterotypic cell-cell adhesion; and positive regulation of cytokine production. Located in several cellular components, including cell-cell junction; cytoplasmic side of plasma membrane; and external side of plasma membrane. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD2 (CD2 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd2 Products(1)

mRNA Protein Name
NM_013486.2 NP_038514.1 T-cell surface antigen CD2 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
1383383 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1383383 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
1383383 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8125140 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
1383383 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
1383383 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

T-cell surface antigen CD2

LFA-3 receptor

T-cell surface antigen T11/Leu-5

lymphocyte antigen 37

Recombinant Cd2 Proteins

Cat. No. Product Name Accession Purity
HY-P74323 CD2 Protein, Mouse (HEK293, His) NP_038514.1 (R23-S203) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-158109 M3554 99.39% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99904 Siplizumab Inhibitor 99.83% Phase 2
HY-P99757 Nivatrotamab Inhibitor 99.40% Phase 2
Pre-clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990286 Anti-Rat CD2 Antibody (OX-34) / Unkown
HY-P990868 Anti-CD2 Antibody (CB.219) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd2 NCBI NCBI:914
Canis familiaris Cd2 NCBI NCBI:607448
Macaca fascicularis Cd2 NCBI NCBI:102120798
Canis lupus familiaris Cd2 NCBI
Leporidae Cd2 NCBI
Rattus norvegicus Cd2 NCBI NCBI:497761
Macaca mulatta Cd2 NCBI NCBI:677855