2. Immunology/Inflammation
  3. CD2
  4. Siplizumab

Siplizumab  (Synonyms: MEDI-507)

Cat. No.: HY-P99904 Purity: 99.83%
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Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody against CD2. Siplizumab depletes T cells, decreases T cell activation, inhibites T cell proliferation and enriches naïve and bona fide regulatory T cells.

For research use only. We do not sell to patients.

CAS No. : 288392-69-8

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Based on 1 publication(s) in Google Scholar

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Description

Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody against CD2. Siplizumab depletes T cells, decreases T cell activation, inhibites T cell proliferation and enriches naïve and bona fide regulatory T cells[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Humanized
In Vitro

Siplizumab (MEDI-507; 0.00001-10 nM) binds to FcγR and induces signal transduction[1].
Siplizumab (0.0001-10 μg/mL) mediates cell depletion and decreased T cell proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Siplizumab Related Antibodies
Clinical Trial
Molecular Weight

145500.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Siplizumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human CD2 Protein (ECD, His Tag) can bind Siplizumab. The EC50 for this effect is 1.441 ng/mL.
  • Loaded Siplizumab on AHC2 biosensor, can bind CD2 Protein, Human (HEK293, His, HY-P7882) with an affinity constant of 3.775E-09 M as determined in BLI assay.
Purity & Documentation
References
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Siplizumab Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siplizumab288392-69-8MEDI-507MEDI507MEDI 507CD2Cluster of differentiation 2monoclonal antibodyIgG1cancerT-cellInhibitorinhibitorinhibit

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