1. Gene
  2. CRNN - cornulin Gene

CRNN - cornulin Gene

Homo sapiens

Also known as DRC1; PDRC1; SEP53; C1orf10

Gene ID: 49860 | Gene type: protein coding

About CRNN

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:152,409,243-152,414,263 (from NCBI)

This gene has 1 transcript (splice variant), 327 orthologues and 21 paralogues. Restricted expression toward esophagus (RPKM 2138.4).

Summary

This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]

CRNN Products(1)

mRNA Protein Name
NM_016190.3 NP_057274.1 cornulin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell-cell adhesion IDA
IDA: Inferred from direct assay
2631556 GOA
involved in cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
30009832 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in positive regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
30009832 GOA
involved in response to heat IDA
IDA: Inferred from direct assay
11606197 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15854041 GOA
located in membrane IDA
IDA: Inferred from direct assay
2980212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRNN Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (4 - 45)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
Protein Preferred Names Protein Names

cornulin

53 kDa putative calcium-binding protein

Recombinant CRNN Proteins

Cat. No. Product Name Accession Purity
HY-P70116 Cornulin Protein, Human (His) Q9UBG3 (M1-S140) ≥95%

Related Diseases

Diseases Alias
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin

Oral Squamous Cell Carcinoma

Mouth Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Mouth

Psoriasis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta CRNN VGNC VGNC:71397
Mus musculus CRNN MGD MGI:2685861
Canis familiaris CRNN VGNC VGNC:39626
Rattus norvegicus CRNN RGD RGD:1311778
Bos taurus CRNN VGNC VGNC:27722
Others CRNN NCBI