OVOL1 - ovo like transcriptional repressor 1 Gene

Homo sapiens

Also known as HOVO1

Gene ID: 5017 | Gene type: protein coding

About OVOL1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,787,063-65,797,214 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 29 paralogues. Biased expression in esophagus (RPKM 10.0), testis (RPKM 9.1) and 9 other tissues.

Summary

This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

OVOL1 Products(1)

mRNA	Protein	Name
NM_004561.4	NP_004552.2	putative transcription factor Ovo-like 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OVOL1 Protein Structure

zf-H2C2_2

0
100
200
267 a.a.

Protein Preferred Names

Protein Names

putative transcription factor Ovo-like 1

ovo homolog-like 1

OVOL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OVOL1	O14753	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	OVOL1	O14753	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	OVOL1	O14753	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	33961781
Intra	OVOL1	O14753	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Conjunctival Intraepithelial Neoplasm

Intraepithelial Neoplasia Of Conjunctiva

Conjunctival Intraepithelial Neoplasia

Fetal Encasement Syndrome

Cocoon Syndrome	COCOS
Fetal Diseases

Popliteal Pterygium Syndrome

PPS	Faciogenitopopliteal Syndrome
Facio-Genito-Popliteal Syndrome	Popliteal Web Syndrome
Autosomal Dominant Popliteal Pterygium Syndrome	Cleft Lip/Palate, Paramedian Mucous Cysts Of The Lower Lip, Popliteal Pterygium, Digital And Genital Anomalies
Popliteal Pterygium Syndrome 1	Cleft Lip/Palate Paramedian Mucous Cysts Of The Lower Lip Popliteal Pterygium Digital And Genital Anomalies
Popliteal Pterygium

Osteogenesis Imperfecta, Type Xii

Osteogenesis Imperfecta Type 12	OI12
Osteogenesis Imperfecta Type Xii	Oi, Type Xii
Osteogenesis Imperfecta 12	Oi Type Xii
Oi-Xii	Osteogenesis Imperfecta Sillence Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09883	OVOL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OVOL1	VGNC	VGNC:75728
Felis catus	OVOL1	VGNC	VGNC:68665
Mus musculus	OVOL1	MGD	MGI:1330290
Canis familiaris	OVOL1	VGNC	VGNC:44196
Bos taurus	OVOL1	VGNC	VGNC:32505
Rattus norvegicus	OVOL1	RGD	RGD:1306956

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