P2RX4 - purinergic receptor P2X 4 Gene

Homo sapiens

Also known as P2X4; P2X4R

Gene ID: 5025 | Gene type: protein coding

About P2RX4

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,210,129-121,234,106 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 18.6), colon (RPKM 15.4) and 25 other tissues.

Summary

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

P2RX4 Products(11)

mRNA	Protein	Name
NM_001261397.2	NP_001248326.1	P2X purinoceptor 4 isoform 3
XM_047428911.1	XP_047284867.1	P2X purinoceptor 4 isoform X3
NR_046372.2
XM_011538416.3	XP_011536718.1	P2X purinoceptor 4 isoform X2
XM_047428910.1	XP_047284866.1	P2X purinoceptor 4 isoform X1
NM_001261398.2	NP_001248327.1	P2X purinoceptor 4 isoform 4
NR_046373.2
NM_175568.1
NM_175567.1
NM_001256796.2	NP_001243725.1	P2X purinoceptor 4 isoform 1
NM_002560.3	NP_002551.2	P2X purinoceptor 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadherin binding	IPI IPI: Inferred from physical interaction	12088286	GOA
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	9016352	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9016352	GOA
enables ligand-gated calcium channel activity	IDA IDA: Inferred from direct assay	9016352	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	9016352	GOA
enables purinergic nucleotide receptor activity	IMP IMP: Inferred from mutant phenotype	11606481	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	17264311	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	9016352	GOA
involved in cellular response to ATP	IDA IDA: Inferred from direct assay	10515189	GOA
involved in membrane depolarization	IDA IDA: Inferred from direct assay	9016352	GOA
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	10515189	GOA
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	15130891	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	21106936	GOA
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	10969036	GOA
involved in positive regulation of calcium ion transport into cytosol	IMP IMP: Inferred from mutant phenotype	10899068	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	10969036	GOA
involved in positive regulation of calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	10899068	GOA
involved in positive regulation of endothelial cell chemotaxis	IMP IMP: Inferred from mutant phenotype	21106936	GOA
involved in purinergic nucleotide receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11606481	GOA
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	11606481	GOA
involved in regulation of cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	11606481	GOA
involved in relaxation of cardiac muscle	IMP IMP: Inferred from mutant phenotype	11606481	GOA
involved in response to ATP	IDA IDA: Inferred from direct assay	9016352	GOA
involved in response to fluid shear stress	IDA IDA: Inferred from direct assay	10969036	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	9016352	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell junction	IDA IDA: Inferred from direct assay	12088286	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	9016352	GOA
located in membrane	IDA IDA: Inferred from direct assay	17785580	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12088286	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23303206	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	10515189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RX4 Protein Structure

P2X_receptor

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 4

ATP receptor	ATP-gated cation channel protein
P2X receptor, subunit 4	purinergic receptor P2X, ligand gated ion channel, 4
purinergic receptor P2X4	purinoceptor P2X4

P2RX4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	P2RX4	Q99571	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	P2RX4	Q99571	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	P2RX4	Q99571	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	P2RX4	Q99571	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	P2RX4	Q99571	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	P2RX4	Q99571	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	P2RX4	Q99571	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	P2RX4	Q99571	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09906	P2RX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09907	P2rx4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09908	P2rx4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	P2RX4	VGNC	VGNC:68671
Canis familiaris	P2RX4	VGNC	VGNC:44210
Mus musculus	P2RX4	MGD	MGI:1338859
Macaca mulatta	P2RX4	VGNC	VGNC:75734
Rattus norvegicus	P2RX4	RGD	RGD:62073
Bos taurus	P2RX4	VGNC	VGNC:32520

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